Our paper on endomitosis in human hepatocyte organoids is now out in JCellBiol 🥳
Proud of Gabriella Darmasaputra and Cindy Geerlings for their hard work, and grateful to our collaborators and reviewers (through Review Commons) for all their input and help!

doi.org/10.1083/jcb.20…

While human fetal hepatocytes can be robustly grown as #organoids , adult primary #hepatocyte organoids remain difficult to expand. Delilah Hendriks et al have solved this expansion issue by adding Il6 and FXR activator to the medium doi.org/10.1038/s41467…

In my lab at the PrinsesMáximaCentrum, Princess Máxima Center for pediatric oncology (in Utrecht NL), we're looking for a great postdoc to focus on immunotherapy and organoid technology. For more info, check: werkenbijprinsesmaximacentrum.nl/vacature/postd…

Researchers have developed a new organoid model that can be used to study the thymus. This model presents new opportunities to study thymus function and can bring insights into the treatment of patients with impaired thymus function. Read more: hubrecht.eu/organoid-model…

Sangho Lim and collaborators report mouse #thymus #organoid lines that can be expanded for years, represent cortex and medulla and sustain T cell development in vitro and in vivo. The Clevers Lab cell.com/cell-reports/f…

I look forward to seeing you all @led3hub lecture later this week

What a win for Roche and a warm welcome to Juergen. With his efforts and leadership of IHB, more bridges will form between academia and pharma to enable better and faster drug development. The Knoblich Lab

🔬Paper alert!🔬We used our next-gen CRISPR tool pipeline to rapidly model 7 common FBXW7 mutations in colon organoids and show their effect on the EGFR pathway. Great collaborative effort with Matteo Boretto, Shashank Gandhi & Hans Clevers, The Clevers Lab. pnas.org/doi/10.1073/pn…

🔍Understanding genetic mutations & signaling pathways is key to advancing personalized therapies for #ColorectalCancer . This study is a crucial step toward more effective treatments. Learn more: pnas.org/doi/10.1073/pn… #CancerResearch #FBXW7 #EGFRSignaling

We (Cayetanopm,Jens Puschhof Joske Ubels, Hans Clevers, van Boxtel lab and all others ) are happy to share our new study on colibactin-mutagenesis in organoids and distinctive features in colorectal cancer doi.org/10.1016/j.ccel…. #Cancer #Organoids #Microbiome

Tour and dinner at Westminster Abbey at the occasion of the annual scientific advisory board of The Crick Institute

Many adult stem cells remain to be identified.Together with #TeamIHB ’s Joep Beumer, we review the current state of knowledge, highlight their complexity and potential to make new models and approaches for drug discovery. 👉🏻Read more: spkl.io/60184ar4C

Proud and grateful to see our foundational articles uncovering the role of #Snail as a repressor of E-Cadherin highlighted in Nature Cell Biology.

Angela Nieto
Instituto de Neurociencias UMH-CSIC
Antonio García de Herreros HMar Research Institute

#ResearchMilestones #CancerResearch
#EMT

nature.com/articles/s4155…

Online Now! Human conjunctiva organoids to study ocular surface homeostasis and disease dlvr.it/T1FrpS #stemcells

🧠Scientists PrinsesMáximaCentrum & Hubrecht Institute unlocked a new method to study brain development with brain #organoids from fetal tissue. This could revolutionize our understanding of brain development & diseases. Delilah Hendriks benedetta artegiani Read more: go.roche.com/g4p2x

Our paper on tissue-derived human fetal brain organoids out in Cell! We derive regional organoids, show the importance of tissue integrity, uncover morphogens influencing regional identity, and created brain tumor models.
benedetta artegiani Hans Clevers
cell.com/cell/fulltext/…

Happy New Year! We're ringing in 2024 with lots of great papers and an exciting Reviews series on the Hallmarks of Stem Cells! Check out the flagship Review from Hans Clevers & Joep Beumer on Hallmarks of stemness in mammalian tissues. More to come! cell.com/cell-stem-cell…

Thrilled about our Cell Stem Cell review on adult stem cells (ASCs) with #TeamIHB 's Joep Beumer. 6 biological hallmarks define their regenerative capabilities and provide insights into tissue-specific strategies for tissue maintenance. Paper👉🏻bit.ly/4aWXbIX