I'm looking forward to speaking at this Harvard Medical School Center for Computational Biomedicine meeting on protein structure prediction! I'll be talking about integrating AlphaFold structural predictions with HMSBioPlex to dramatically improve our understanding of the interactome.

Don't miss this preprint from our colleagues Ernst Schmid and Johannes Walter in Harvard Med BCMP. We expect their work with AlphaFold will be an important complement to many of our proteomics projects, from HMSBioPlex to PTM profiling, chemoproteomics, and more!

Check out this talk to learn about recent developments in the Gygi Lab, including work we've been doing in HMSBioPlex!

It's great to have Steve over in Europe sharing our latest work on PPI as well as other recent efforts from the Gygi Lab!

Do you want to hear about the latest developments in the HMSBioPlex project? Check out Ed Huttlin's #ASMS2024 talk tomorrow: MOH 10:10. See you there!

If you're at #ASMS2024 in Anaheim, don't miss these exciting posters and oral presentations from Gygi Lab members throughout the week!

Good morning! I'm looking forward to presenting our latest HMSBioPlex work combining PPI mapping with protein structure prediction using AlphaFold. Check it out in session MOH at 10:10 am!

Join our dynamic team! My lab UMass Chan Medical School is seeking postdocs passionate about creating cutting-edge intelligent quantitative (chemo)proteomics platforms. Let's decode protein function and develop novel therapeutics! DM me for a chat and apply at ummsjobs.com/job/10402/

Today we celebrated the end of an era as Qing Yu wraps up several highly productive years in the lab! Though we'll miss him, we wish him the best as he starts his own group, and we're glad he'll still be nearby at UMass Chan Medical School.

It's always gratifying to see how our BioPlex network can help people to advance their research!

Proteomics Turns 30! It is thirty years since Prof. Marc Wilkins (then an early career researcher) introduced the term "proteomics" at the International Meeting on "2D Electrophoresis: From Protein Maps to Genomes" in Sienna (Italy). #proteomics

It's great to see BioPlex alumnus Jose Navarrete-Perea featured in this month's issue of JASMS! While at Harvard, Jose was a key member of the BioPlex team, keeping our instruments in shape while running thousands of AP-MS samples. Am Soc for Mass Spec Gygi Lab pubs.acs.org/doi/10.1021/ja…

🚨 New in Nature nature! 🚨 Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐 📝 Paper: nature.com/articles/s4158… 🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/

Check out MuSIC 2.0, combining Human Protein Atlas images and HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with Trey Ideker, Emma Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & Clara (Mengzhou) Hu!

Protein interaction networks are powerful tools for biological discovery, and they're even better when combined with imaging data. Want to learn more? Check out the latest MuSIC paper! Human Protein Atlas HMSBioPlex Leah Schaffer Clara (Mengzhou) Hu Emma Lundberg Trey Ideker Ed Huttlin

It’s also worth mentioning that the AP-MS data in this study was collected by the HMSBioPlex team at Harvard Medical School.

#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how HMSBioPlex is enhancing drug discovery! Harvard Medical School Am Soc for Mass Spec

If you're going to #ASMS2025, don't miss these presentations from members of the Gygi lab! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging HMSBioPlex for drug discovery, new instrumentation, and much more! @edhuttlin Steven Shuken Amanda Smythers, PhD