According to a landmark observational study totalling 15,638 patients just published in The BMJ, combinig GLP-1 receptor agonists and SGLT-2 inhibitors was associated with a lower risk of major adverse cardiovascular events and serious renal events compared with either drug…

Great work (currently being updated) led by Isha Mishra, one of the many 🌟 honours students at Centre for Pain Impact

New meta-analysis in The BMJ about the treatment of depression with psilocybin🍄
Despite its positive conclusions, the authors make the most recurrent errors in meta-analyses

Let's see if by pointing them out we can make them less and less frequent🧵
dx.doi.org/10.1136/bmj-20…

My first poster presentation at the ESSA Research to Practice 2024 conference #RTP24 #ESSA

Centre for Pain Impact

Amazing work from Yannick Gilanyi, two important projects to understand how to get, and keep people with low back pain exercising. AND both completed during his Honours! 👏
Centre for Pain Impact ESSA

Just published!

The POWER study investigated whether #physiotherapists can deliver a clinically effective very low energy #diet alongside an exercise intervention for those with knee #osteoarthritis

Results below 👇

Article in British Journal of Sports Medicine (BJSM) here: bjsm.bmj.com/content/58/10/…

“When we recommend the best treatment for patients on the basis of their individual characteristics, we are applying the concept of heterogeneity of treatment effect.” Read the full editorial by Drs. Christopher J. Yarnell and Michael Fralick: eviden.cc/3TuT2DP

We are thrilled that the preprint of our profile paper on the development of the MedIntel Data Platform is now available. The Medicines Intelligence Data Platform: A population-based data resource from New South Wales, Australia medrxiv.org/content/10.110… 🧵1/4

👀 Seeking people with an upcoming hip/knee replacement surgery!

We want to talk to you & hear your concerns/expectations about the pain medicines you will be given when you go home from hospital.

Please complete this survey if you'd like to get involved redcap.sydney.edu.au/surveys/?s=PAC…

Marion Campbell Brennan Kahan And Suzie Cro is leading important work on how to involve patients and the public in discussions about estimands. The co-developed tool in this paper is a great starting point trialsjournal.biomedcentral.com/articles/10.11…

Reporting health and medical research

Part of the OA series - #Analysis led by Harrison Hansford et al.

Link: bit.ly/3Q1uJwm

If trainees do a research project with me:
1. It’s a problem I’ve identified as relevant/important, which is guided by my knowledge of uncertainties in the field of EBM/EBHC;
2. You do it as a team;
3. You lead it to the end

My way of improving noise:signal

.Brennan Kahan is publishing some really helpful papers on the estimands approach eg he and others wrote a very helpful explainer on the E9 addendum. Follow Brennan to stay up to date with developments 8/8
Addendum explainer:
bmj.com/content/384/bm…

A word we hear a lot about currently in the trials world is #Estimands .  But what are they and why are they useful? 1/8
#MethodologyMonday #85

So much potential wasted…

Huberman had an opportunity to pass on to millions positive evidence based information around back pain yet instead focuses on McGill Big 3 and Mckenzie extensions 🤦‍♂️

This will negatively affect evidence based back pain healthcare for years! 😖

here's what BOCSAR's map looks like, which defaults to incidents per 100,000

On Monday 13 May, join researchers Dr. Anastasia Shavrova 🕷️ (she/her), Yannick Gilanyi, Indrani Mukherjee and Sarah McInnes as they look on the bright side with their series:

‘It’s not all bad! The other side of negative emotions and environments’
pintofscience.com.au/event/its-not-…

This graph in The Sydney Morning Herald doesn't account for population size. Blacktown has a population of ~426000, Mosman ~28000, and Hunters Hill ~14000.

Exercise Therapy for Post–COVID-19 Condition—Does No Harm jamanetwork.com/journals/jaman… via Oliver OSullivan et al