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2022 highly publicized consensus statement advocated toward COVID-19 elimination. No evidence summary. Just published commentary reports panelists chosen on basis of prior views. Need balanced panels, recommendations based on structured evidence summaries. jclinepi.com/article/S0895-…

Optimizing use of predictive models requires integration with decision analysis. Decision curve analysis facilitates, but thus far requires individual patient data. Recently published paper shows how to conduct DCA with aggregate data. doi.org/10.1111/jep.13…

We all struggle with negative feedback, and when we provide negative feedback struggle to find ways that will be less painful for both ourselves and the recipient. One solution: sandwich approach. Start and end with laudatory feedback; between the two suggestion for improvement.

Recent critique of non-inferiority trials demonstrates how they needn’t be so baffling for clinicians: just approach same as superiority looking at benefits/harms/burdens of the alternatives. More about this revolutionary approach coming soon. doi.org/10.1016/j.euf.…

In Geneva, helping to produce guideline for the WHO covering management of all 4 major Arboviruses including Dengue.

As instrument for assessing clinical practice guideline quality AGREE 2 has major limitations including complexity and burden. NEATS more straightforward, but limitations of clarity. Just published NEATS modification much improved. doi.org/10.1002/gin2.1…

Recently published shocker regarding prediction of patient outcomes. Clinical intuition often as good, sometimes better than formal prediction models. jclinepi.com/article/S0895-…

Developing definitions of new diseases a major challenge for emerging rare diseases. Here a model for rigorous development, hypophosphasia: collaboration of methodologists & experts, including system surveys of published expert opinion and of case series. doi.org/10.1007/s00198…

Industry publishes randomized trials that make their products look good by choosing suboptimal comparators inconsistent with current clinical practice (e.g. new antipsychotics less side effects versus overdose of existing drugs). This paper many examples. doi.org/10.1177/014107…

Innovative, original use of indirect evidence in network meta-analysis shows promise of wider application. pubmed.ncbi.nlm.nih.gov/37739191/

On our back deck with friends including Andrea (to my right) who is leading GATES foundation initiatives against polio and mpox (no longer monkeypox to respect the blamelessness of the monkeys) in the Democratic Republic of the Congo.

Most recent, bang-on, straightforward, simple approach to differentiating trustworthy versus untrustworthy guidelines. doi.org/10.1136/fmch-2…

Recent post about shocker showing clinical intuition often as good, sometimes better than formal prediction models generated interest. Here demonstrating the relation between the two in discrimination. Axes are c-statistic.sciencedirect.com/science/articl…

In the slightly bizarre, overhyped, and highly manipulated world of impact factor, some may be surprised that to the chagrin of the NEJM, Lancet has overtaken (NEJM latest 96.2, Lancet 98.4) and BMJ extraordinary jump (30.2 in 2019, now 93.6)

Making results of patient-reported outcomes in SRs easily interpretable to audience – is magnitude of effect trivial, small, moderate, or large – presents challenges. This review documents how Cochrane reviews are currently handling the challenge. pubmed.ncbi.nlm.nih.gov/37028685/

Care based on patients' risk of adverse outcomes has potential to enhance personalized care. Studies evaluating risk-guided care use variety of study designs. This overview presents key design features to recognize and produce trustworthy results. pubmed.ncbi.nlm.nih.gov/37852391/

When recently asked about sources of my academic motivation, initial response: commitment, challenge, and ambition. Subsequently more thoughtfully, the deep satisfaction of supporting an extraordinary array of deeply committed people in a common cause. Finally, great deal of fun.

A recent JAMA Users’ Guide provides the optimal approach to interpret and use a clinical practice guideline. pubmed.ncbi.nlm.nih.gov/34665198/

Just published systematic review found moderate certainty evidence that monitoring oncology patients’ status by asking them to complete patient-reported outcome measurement instruments reduces mortality and improves quality of life. Remarkable! pubmed.ncbi.nlm.nih.gov/39136947/

My best advice for collaboration and career for young researchers. pubmed.ncbi.nlm.nih.gov/33545269/