🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🚨New Paper Alert🚨 Our new #microbiome research, co-led with Liat Shenhav, published today in Cell! We show that #breastfeeding "paces" gut & nasal microbiome development to prevent #asthma in the CHILD Cohort Study. #Tweetorial 🧵 cell.com/cell/fulltext/…

These molecules stimulate appetite and promote fat storage, aligning the host’s metabolism with the environment’s feast-famine cycles. cell.com/cell/fulltext/…

The FG-PG relationship functions as a feedback system, where each guild’s growth regulates the other, preventing unchecked dominance and maintaining dynamic equilibrium. cell.com/cell/fulltext/…

This balance enables the microbiome to act as an adaptive nutrient sensor, modulating host responses like appetite, satiety, and energy storage based on environmental cues. cell.com/cell/fulltext/…

In a natural cycle of feast and famine, this competition encourages energy storage during abundance and conservation during scarcity. cell.com/cell/fulltext/…

In modern environments with constant food abundance and low fiber intake, however, this adaptive balance is disrupted. Chronic PG dominance leads to persistent low-grade inflammation, insulin resistance, and excessive energy storage. cell.com/cell/fulltext/…

This imbalance exemplifies how the FG-PG competition, although adaptive, becomes maladaptive in today’s dietary landscape, where one guild is consistently favored. cell.com/cell/fulltext/…

Thus, the stable competition between FG and PG is fundamental to the microbiome’s role as an adaptive nutrient sensor. cell.com/cell/fulltext/…

It illustrates how dietary choices shift the balance toward either health or dysfunction, suggesting that restoring FG dominance through fiber-rich diets could recalibrate this balance, realigning it with the microbiome’s evolutionary purpose. cell.com/cell/fulltext/…

Restoring and maintaining the TCG structure in the gut microbiome is therefore essential for it to function as a dynamic regulatory interface between the host and the environment. cell.com/cell/fulltext/…

In essence, stability within guilds like FG and PG reflects an evolutionary adaptation, enabling the microbiome to sustain functions under environmental pressures that a less connected population could not. cell.com/cell/fulltext/…

This concept of stability of relationships as a marker of functional significance is central to understanding the microbiome as a complex adaptive system, where the resilience of microbial networks is directly linked to host health. cell.com/cell/fulltext/…

What kind of analytical strategy would allow you to integrate 38 different microbiome studies and identify a set of 284 genomes of core bacteria into Two Competing Guilds as an indicator of Health: the guild-based analysis! cell.com/cell/fulltext/…

Guild-based analysis of microbiome data has three pillars, the first is genome-specific analysis with high resolution and granularity than any taxa. High quality metagenome-assembled genomes (MAGs) are the basic features. jci.org/articles/view/…

The second pillar of guild-based microbiome data analysis is database independence. Each high quality MAG is given a Universal Unique Identifier (UUID) and tracked in samples across different studies for data integration and mining. jci.org/articles/view/…

The third pillar of guild-based microbiome data analysis is interaction focused perspective. Co-abundance network analysis of high quality MAGs is used to identify potential guilds jci.org/articles/view/…

Meet Evo, the DNA-trained AI that creates genomes from scratch | Science | AAAS science.org/content/articl…

Immensely grateful to all experts who contributed this piece with their expertise and efforts! Nicola Segata Segata Lab Giovanni Cammarota Harry Sokol Francesco Asnicar Siew Ng Liping Zhao Richard Hansen RaesLab Georgina Hold Christian Hvas KorenLab Hein M. Tun Mireia Valles-Colomer MCarmen Collado Edoardo Pasolli

Researchers, including CIFAR's Liping Zhao, have developed a new method to identify crucial gut microbes essential for health. 🦠 This discovery could lead to precision nutrition and personalized therapies for managing diabetes, IBD and more. medicalxpress.com/news/2024-10-a…

🎉Huge congratulations to our Editor-in-Chief, Dr. Jizhong Zhou, on being elected to the National Academy of Sciences! This prestigious honor recognizes his outstanding contributions to Microbial Ecology. We are proud and thrilled! National Academy of Sciences nasonline.org/news/2025-nas-…