Honored to receive an ERC Advanced Grant to study the interaction of the chromatin landscape with 3D genome organization in Epigenetic Cell Memory 🎆 🍾 Very excited to start exploring these basic mechanisms that maintain cell identity across our lifespan 🤩 The Groth Lab CPRatUCPH

Our latest publication on the multi-talented J-domain protein and histone chaperone DNAJC9 is open for access📖Balachandra et al EMBO J 2024! 🧵 #JDP #histone_chaperone CPRatUCPH Inst of Systems, Molecular & Integrative Biology NCI Center for Cancer Research tinyurl.com/DNAJC9-CENPA

Very pleased to see my amazing colleague Anja Groth 🇺🇦 receive a #ERCAdG - very well deserved! A great achievement for a great lab!

What a b(y)east! Using S. pombe, we demonstrate that replication fork component Mrc1 (CLASPIN in mammals) functions to recycle ♻️parental H3-H4 to BOTH leading and lagging strand ☯️! Affecting recycling symmetry leads to a clonal loss of heterochromatin and #epigenetic memory⬇️🧵

New regulator of epigenetic cell memory in the replisome ♻️🧬 Cell tinyurl.com/ycymebr6 . Shoutout to Sebastian Charlton Vale Flury for outstanding teamwork 🙌, Genevieve Thon for bringing us into fission yeast heterochromatin, and Masai lab Guillermo Montoya @Fmattiroli 👏

Now online! The fork protection complex promotes parental histone recycling and epigenetic memory dlvr.it/TBRfcV

🚨 Job Alert! 🚨 The Groth Lab is seeking a passionate #postdoc for a translational project on novel epigenetic approaches to cancer treatment 🧫🥼. We value idea sharing and use Creative Problem Solving to drive our innovative research. More info here 👇! employment.ku.dk/faculty/?show=…

Former Groth lab member Kathleen Stewart-Morgan is hiring post-docs in beautiful Copenhagen. Check it out here: 👇

This is a great preview of the recent works describing Mrc1 in H3-H4 histone recycling ♻️ during DNA replication. Check it out below 👇 or our full paper in the latest Cell here: tinyurl.com/ycymebr6