T-ALPHA: A Hierarchical Transformer-Based Deep Neural Network for Protein-Ligand Binding Affinity Prediction With Uncertainty-Aware Self-Learning for Protein-Specific Alignment 1. Introducing T-ALPHA: A state-of-the-art hierarchical transformer designed to predict protein-ligand

sciencenews.org/article/cancer…

I’ve noticed that while sleep deprived, my cognition is much sharper if I’ve taken creatine (5-10g) — an effect supported by this study: nature.com/articles/s4159… Curious whether the effect compounds with caffeine — a 2x2 factorial study would be valuable: control vs. creatine vs.

At some point over the last few hundred years, wisdom and intelligence decoupled. Modern-day intelligence seems to be largely IQ-dependent — raw processing speed, pattern recognition, etc. Socrates, Marcus Aurelius, Plato, Aristotle, Kierkegaard, Tolstoy, Dostoevsky — likely

Negative energy seems to (1) spread through human networks much more spontaneously than positive energy, and (2) increase social fragmentation — both of which are commensurate with an increase in Shannon entropy. I wonder if this has to do with the 2nd law of thermodynamics. Of

Finally had a chance to listen through this pod with Sutton, which was interesting and amusing. As background, Sutton's "The Bitter Lesson" has become a bit of biblical text in frontier LLM circles. Researchers routinely talk about and ask whether this or that approach or idea

An exciting milestone for AI in science: Our C2S-Scale 27B foundation model, built with Yale University and based on Gemma, generated a novel hypothesis about cancer cellular behavior, which scientists experimentally validated in living cells.  With more preclinical and clinical tests,