The ^ episode has already proven incredibly popular. Following hot on the heels of a wonderful chat with Chris Stringer on the origins of homo sapiens. 🎧 podfollow.com/the-ancients/e…

"For schizophrenia, the chance of getting a diagnosis is ~40% if a genetic clone (an identical twin) is also affected" My short overview of the history, current state, and future of psychiatric genetics 🧬🧠 English: drive.google.com/file/d/1sMd2ep… Dutch: tijdschriftvoorpsychiatrie.nl/nl/artikelen/a…

A fantastic interview with UK Dementia Research Institute Prof Tara Spires-Jones. Very balanced and well worth a listen 👇

Didn’t think I could top my last NYT quote, but I think I might have done it with this one 😂 nytimes.com/2024/08/23/opi…

A new #ScienceReview compares and contrasts the processes involved in traditional randomized clinical trials and newer decentralized clinical trials. 📄: scim.ag/8aj

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

Matthew Yglesias @_alexa_blue In good faith, then, I would like to use this opportunity to help you (and any others!) learn to distinguish between “the placebo effect” and “regression to the mean” for your future reference.

The symptoms of depression might come and go, but new evidence suggests that the pattern of brain wiring behind it remains the same for life go.nature.com/3yXXLIh

« Mega-trials (MG) need to be performed more often, given the relative low number of MG found, their low significant rates, and the fact that smaller trials published prior to MG reported more beneficial results than MG and subsequent smaller trials. » jamanetwork.com/journals/jaman…

Meta-analysis of 17 phase 3 MS DMT trials shows higher comorbidity burden is associated with increased risk of relapse and disability progression. ja.ma/3XNhfJa #ECTRIMS2024

#ECTRIMS2024: Society fellow Dr. Amber Salter (Dallas, TX) - Data from 16,794 MS trial participants shows that comorbid (coexisting) conditions make clinical outcomes worse. Read more: ntlms.org/3TvXxiA Get tips for managing comorbidities: ntlms.org/4e5ZMBt

Kowalec (US) effect of genetic predisposition for depression on disease activity in #MS. Higher risk of relapse and EDSS progression in persons with higher predisposition for depression! Importance of comorbidity on MS disease course! #ECTRIMS2024

Chataway (UK): MS-stat2 study on simvastatin 80mg vs placebo in SPMS. Large phase 3 trial, unfortunately no significant effect on confirmed progression 🤷🏻‍♂️ #ECTRIMS2024

🎙️ In case you missed it, listen to Prof. Alan Thompson from @UCL wrap up #ECTRIMS2024 and dive into all things ECTRIMS with host Brett Drummond from MStranslate on the #ECTRIMSPodcast Spotify ➡️ spoti.fi/4gAbvcO

Proud to be part of the coalition for mental health investment find out how you can get involved mentalhealthinvestment.org

Science #Immunology's October issue is out! This month's cover highlights how #NFkB signaling helps recruit the noncoding RNA Xist to maintain #XChromosomeInactivation in activated T cells. Read this research and more: scim.ag/8p0

Can memantine and/or trazadone slow ALS progression? Nope. A brand new large randomized study out by Pal and colleagues The Lancet Neurology. Can we test multiple drugs at once by sharing a placebo or control arm? Yep. Key Points: - The authors point that ALS and motor neuron disease

Aging is an energetic process But how and where do cellular and whole-body energy demands and availability interact? The Brain-body Energy Conservation (BEC) model of aging argues that the brain brokers the energy budget, driving aging manifestations nature.com/articles/s4358…

The human genome is littered with pleiotropic variants with conflicting effects on disease traits, for e.g., increase the risk of one disease but protect against another, or is detrimental early in life but beneficial later. A fascinating new preprint systematically studied this

🚀 What if the next breakthrough medicine is already on the shelf? 💊 Faster, cheaper treatments through drug repurposing—join #iDR25, 7-8 May 2025 in Amsterdam! 🔗 remedi4all.org/2025-internati… #ERAMETProject #DrugRepurposing