Today we’re celebrating the groundbreaking of the latest addition to Children's Hospital’s research campus, the Schuylkill Avenue Research Building.

📢 A novel gene therapy for #Dravet. jci.org/articles/view/…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.

New paper from UPenn MDPhD students past (Kevin Goff), present (Sophie) and future (Evan Jiang): cell.com/cell-reports/f… VIP-INs are dysfunctional in Dravet syndrome (Scn1a+/-) mice in vivo; deletion of Scn1a in VIP-INs dissociates autism-linked behavior from epilepsy

Thanks to NINDSfunding for support of this preclinical work leading to a candidate therapy for EPM7. This collaboration was led by postdoc Jade Feng with Autifony Therapeutics Manuel Covarrubias Naiara Akizu. We will continue to work to improve the lives of patients with rare disease.

When will I stop having to write things like <i>I</i>_NaP in the Figure Legend dialog box when I am uploading manuscripts for review? <b>This wastes <i>a lot</i> of time!</b> The Figure Legends are already included in the Main Text, where they are formatted correctly.

Postdoctoral Fellowship for Academic Diversity at The Children's Hospital of Philadelphia: - $65K salary in Yr 1, increasing in $2K yearly increments - Annual travel ($2K) allowance and supplies ($4K) - Relocation bonus ($5K) - Supervised research training research.chop.edu/services/postd…

Our new paper studying SCN3A Epilepsy in an IPSC system by postdoc Guojie Qu, Penn NGG superstar Julie Merchant, and sodium channel maestro Jerome Clatot is in @Brain1848 at tinyurl.com/37xve8nr Great collaboration w/ the lab of Stewart Anderson CHOP Research

Another fun collaboration w/ Christopher Currin, PhD 🌍 🇿🇦 & Tim Vogels plus @DelemotteLab and Manuel Covarrubias: Jerome Clatot et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction | PNAS pnas.org/doi/10.1073/pn…

From postdoc Jade Feng: Kv3 modulator targets cell dysfunction in vitro + motor impairment/seizure susceptibility in vivo in mouse model of Progressive Myoclonus Epilepsy Type 7 (EPM7) doi.org/10.1016/j.xcrm… This preclinical data supported ClinicalTrials.gov ID NCT05873062

Superstar Penn NGG student Sophie throws the kitchen sink at Layer 1 Ndnf cells to show unique preservation of Ndnf interneuron excitability among the major neocortical GABAergic interneuron subtypes in a mouse model of Dravet syndrome. jneurosci.org/content/early/…

Excited for Neuroscience 2024: Mechanisms and Emerging Therapies for Brain Disorders of Childhood. All @CHOPResearch and Penn faculty, staff and trainees are welcome. Join us to celebrate groundbreaking research and network with peers! Learn more: pdss.research.chop.edu/agenda.php

We are recruiting to two (2) Tenure-Track Assistant Professor positions in the new BRIDGE Center (Brain Research In Development, Genetics, & Engineering) at The Children's Hospital of Philadelphia/University of Pennsylvania. Details here: apply.interfolio.com/148361

Postdoc Eric Wengert (brain slice physiologist + educator extraordinaire) teams up with Penn NGG MDPhD student Sophie and three Penn undergrads: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy: biorxiv.org/content/10.110…

From postdoc Sophie Hill in a fun collaboration w/ EAP expert Brian Theyel supported by Dravet Syndrome Foundation : Attenuated Ectopic Action Potential firing in PV interneurons in a mouse model of Dravet Syndrome biorxiv.org/content/10.110… The function of EAPs remains under investigation...

Rising star @ZPRosenthal PGY-3 Resident Penn Psychiatry uses a novel mouse model of electroconvulsive therapy (ECT) and DCS/FD-DOS in humans to show that: ECT generates a hidden wave - CSD - after seizure biorxiv.org/content/10.110…

New collaboration with David R. Liu to pursue base editing in a Dravet syndrome model. Thanks to Dravet Syndrome Foundation for your leadership and vision and continued support of our work to improve the lives of patients with Dravet Syndrome. einpresswire.com/article/769708…

Rare variants in epilepsy- and autism-linked gene SCN2A are associated with malformation of cortical development, supporting role of NaV1.2 in early brain development: doi.org/10.1111/epi.18… Fun collaboration w/ Al George Nicola Specchio Renzo Guerrini Supported by NINDS

Please consider applying for the 2025 Gordon Conference on Inhibition and the preceding Gordon Research Seminar on Inhibitory Cascades in the CNS.  grc.org/inhibition-in-……Great lineup

Job Alert! Technical Director to lead the Behavioral Evaluation of Advanced Model Systems (BEAMS) Hub of the BRIDGE Center research.chop.edu/bridge at Children's Hosp of Philadelphia. Great for a senior postdoc or research associate w/ expertise in behavior tinyurl.com/ywbhckj9

Job Alert! Administrative Manager for new Center for Brain Research in Development, Genetics, and Engineering (BRIDGE Center) at the Children's Hospital of Philadelphia to provide admin leadership and support Center operations. Apply here: tinyurl.com/4s5j747p