Wu et al. show that ESR1 mutations promote FOXA1 localization to retinoid X receptor (RXR) motifs in ER+ #breastcancer, sensitizing breast cancer cells to RXR antagonists— bit.ly/3ADoN4N Allie Casey Jay Gertz Jennifer Xavier Adrian Lee Dr. Steffi Oesterreich

Thanks to excellent collaborators on this review exploring AR functions across multiple cancer types! Javier Leo NR IMPACT Endocrine Society The Mike Slive Foundation Liz Wellberg Eleonora Dondossola,PhD Nate Wilson Omar Alhalabi, MD @mcquadeMDLAc Shannon Westin, MD, MPH, FASCO et al pubmed.ncbi.nlm.nih.gov/37154098/

Congrats to Ozlen, Brooke and the rest of the gang for getting this preprint up and the formal manuscript under peer review. biorxiv.org/content/10.110…

I'm hiring! I have a 2-year funded #endometrial #cancer project for a postdoc with #organoid culture experience. Based in Brisbane with views like this, how can you say no? HMU if you have Qs about the role. Applications close 6th June shorturl.at/abhlz

It was an honor to be included as one of the Huntsman Cancer Institute Breast and Gynecologic Cancer Rising Stars yesterday alongside @KLawsonMichod, Dr. Alessandra Riggio, and Dr. Christopher Weil. It's great to see the impactful work being done on women's cancers.

Congrats to Spencer Arnesen and the rest of the team!! Great to see this fun project out in Bill Dynan - NAR Cancer Editor!

.Zannel Blanchard, PhD et al. show the ER-Y537S mutation mediates unique gene expression changes in #endometrialcancer, and identify CDK9 and NCOA3 as potential therapeutic targets. bit.ly/46MD65G Craig Rush Spencer Arnesen A Cristina Rodriguez, Ph.D. Matthew Chang hisham Jay Gertz

The second major publication from Zannel's PhD project in the Jay Gertz is now published in Molecular Cancer Research. I'm thankful to have had the opportunity to help out on this work that further defines the effects of mutant Estrogen Receptor in #endometrialcancer

Our work characterizing ER hotspot mutations in endometrial cancer is out in MCR 🥳 The study highlighted allele-specific differences between ER-Y537S and ER-D538G mutations and identified potential therapeutic targets in this disease.

My pleasure to have officiated the Gordon Conference Hormone Dependent Cancers 2023 Breast Vs Prostate Football Match. The breast team emerged happy & victorious 4-2 🏆🍾 @MagnaniLab_ICR Dr. Steffi Oesterreich Daniel E. Frigo, Ph.D. Damir Varešlija @dralexswarbrick DRMCRL @BevanLab Scott Dehm

Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by Zannel Blanchard, PhD and Jay Gertz, have identified potential new treatment options for people with endometrial cancer. bit.ly/47GqKwn

Want to work in the heart of Dublin where cutting-edge research meets a super friendly lab environment? 🍀 Dive into the world of breast cancer brain metastasis with us. Dublin’s warmth and our team’s camaraderie await you! Apply now: euraxess.ec.europa.eu/jobs/138568

This week is National #PostdocAppreciationWeek. Zannel Blanchard, PhD (Zannel Blanchard, PhD) is a postdoctoral fellow in the Welm lab. She explains the role of a postdoc, what inspired her to become a cancer researcher, and why she loves working here. #HCIproud

We are recruiting! Time to recirculate this work since there’s still so much to do. If you have expertise in DNA damage repair #DDR and are looking for a postdoctoral position where you can lead clinically-relevant discoveries, please don’t hesitate to reach out. KU Medical Center

Our latest review article on estrogen receptor targeted therapies in breast cancer has been published! academic.oup.com/endo/advance-a…

Our work on how enhancers impact estrogen transcription timing and noise is now out in Cell Genomics! Thanks to everyone that helped out on this project! cell.com/cell-genomics/… Matt Ginley Xiaoyang Zhang

This excellent review on estrogen receptor alpha mutations, truncations, heterodimers, and therapies, goes into the history of ERα, current research unlocking unknown aspects of ERα signaling, and future directions of ESR1 investigation Rinath Jeselsohn Jay Gertz pubmed.ncbi.nlm.nih.gov/38643482/

Our latest Review is live! Thanks to ⁦Jay Gertz⁩ and ⁦Rinath Jeselsohn⁩ for your help and ⁦⁦Endocrine Society Journals for publishing⁩! track.smtpsendmail.com/9032119/c?p=1c…

We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, Jay Gertz , and Swneke Bailey.

Glad to share our latest work on The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer models, now published in npj Journals #npjBCancer, shorturl.at/WPiJK, with the super-multifunctional browser estrogeneii.web.app