Excited to share the latest results from the Hani Goodarzi lab & a great collaboration with @AndreiGoga_SF and Faraz K Mardakheh labs! Shout out to the amazing co-authors Hossein Asgharian, Juliane Winkler, @lisacfishsci and many more! biorxiv.org/content/10.110…

This study started with a question: what are the unknowns of translational control in breast cancer metastasis? By combining Ribo-seq and Ribolog, a new tool by Hossein Asgharian for Ribo-seq analysis, we found HNRNPC to control translation of a metastasis suppressing mRNA regulon.

HNRNPC is known as a nuclear regulator of alternative splicing – how could it regulate translation? It turns out HNRNPC interacts with PABPC4, a poorly characterized poly(A) binding protein, and binds target mRNAs near poly(A) signals.

In highly metastatic cells, the lower expression of HNRNPC and PABPC4 results in the 3' UTR lengthening of their target mRNAs and subsequent translational repression, at least partly through an Argonaute-dependent RNAi.

Lower expression of the HNRNPC-PABPC4 axis components increases metastasis in xenograft mouse models and is associated with poor clinical outcomes in breast cancer patients.

Finally, modulating the poly(A) site selection using a small molecule drug reduces the metastatic lung colonization, providing evidence for a therapeutic vulnerability of HNRNPC-low tumors.

Check out the amazing tools developed by Hossein Asgharian for this study here: github.com/goodarzilab/Ri…

and github.com/goodarzilab/AP…

Very excited to share our paper, identifying a tumor-suppressive tRNA synthetase, published today in @naturecellbiol! nature.com/articles/s4155… @sohailtavazoie Hani Goodarzi @triimdphd @rockefelleruniv… 1/11

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

⭐️ONLINE NOW Nature Cancer “Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes” by Hani Goodarzi Sohail Tavazoie & Co. 👇 nature.com/articles/s4301… rdcu.be/c1xq7

Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between Hani Goodarzi, Andrei Goga and Faraz K Mardakheh labs! Shout out to co-authors Hossein Asgharian, Juliane Winkler, @lisacfishsci among others! nature.com/articles/s4155…

Took us a minute, but I am happy to share the final version of this study, now published at Nature Cancer, on behalf of Bruce and Kristle. We have it all, regulatory RNA interactions, oxidative stress/ferroptosis, and metastasis: nature.com/articles/s4301…

Check out the final and peer reviewed version of this preprint published by Cell Reports. Congratulations BrianWooSciAcc and thanks to Felix Feng and LukeGilbert for the support. cell.com/cell-reports/f…