Happy to share our News & Views The EMBO Journal from Kristina Schierhorn, Raul Y Sanchez David and I on the latest study from Yang Li and Shou-Wei Ding's labs! They show that virus-derived #siRNA can enter the bloodstream and confer systemic #antiviral activity. onlinelibrary.wiley.com/share/author/K…

Excited to share our #preprint on a novel drug-like molecule which engages DAF-12/FXR to induce mitophagy & promote mitochondrial mediated lifespan⬆️.Thanks to all the authors! Julie K Andersen Malene Hansen Lab Caroline Kumsta Dhanya Nambiar Angeli Lab Buck Institute researchsquare.com/article/rs-184…

New online│ News and Views by Eric Lieberman Greer (Eric Greer Lab) on the study by Takahashi et al. in Cell reporting a new mouse model with directed DNA methylation to study transgenerational epigenetic inheritance in mammals. nature.com/articles/s4168…

Excited to share our paper out online today! We labeled and tracked heritable non-genetic info transmitted from parents to their children. We found that starvation in ancestors leads to transgenerational phenotypes in naïve well-fed descendants, ... 1/9 sciencedirect.com/science/articl…

📢New article alert from the lab!!!🎉Fantastic effort by Gautam Umanshi Rautela and others👍🏽 A short 🧵.BRIC-NII funding support Department of Biotechnology SERB ICMR journals.biologists.com/dev/article/15…

Development Research Highlight of our article. BRIC-NII Department of Biotechnology SERB ICMR Umanshi Rautela Gautam Manish Chamoli Anita Goyala Anupama Singh

Dr Mukhopadhyay's group BRIC-NII shows how damage to somatic tissues can influence germ cell development🧑‍🔬 Using C. elegans🪱 they show that DNA damage signals 🧬 from uterus can arrest oogenesis🛑 through activated FOXO, a transcription factor More▶️bit.ly/FOXO_DDR

Thanks IndiaBioscience.org for highlighting our study and Banya Kar for beautifully summarising it. BRIC-NII Department of Biotechnology SERB ⭐️⭐️⭐️ for Gautam Umanshi Rautela

A brand new #preprint led by ⭐️grad students 👩‍🔬 Umanshi Rautela and 👨‍🔬Gautam . A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state biorxiv.org/content/10.110… . A 🧵.

A brand new study led by Sabnam Rahman. Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling biorxiv.org/content/10.110… Supported by BRIC-NII Department of Biotechnology SERB

Excited to share a preprint where we have identified that the 18S rRNA Methyltransferase DIMT-1 regulates lifespan by functioning in the germline later in life 1/8 biorxiv.org/content/10.110…

For the latest episode of 'Behind The Bench', we have Umanshi Rautela from Arnab Mukhopadhyay lab at BRIC-NII. She shares with us, her work and her PhD journey. Read here: insdb.in/behind-the-ben…

We have openings in our lab starting soon for a #postdoc and #PhD or #undergrad trainees. Please RT & bring this to the attention of your network. We value curiosity, mentorship, & diversity. Reach out to me for further details. First position apply here. jobs.rutgers.edu/postings/239950

Paper alert!! A different theme (not aging!) published in @plosgenetics. Led by @Umanshi and Gautam , we show a novel genetic interaction between Cyclin D and FOXO transcription factor in oocyte quality assurance and reproductive fidelity. journals.plos.org/plosgenetics/a…

Excited to share my first-author publication in Nature Communications! Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour & longevity via neuron-gut signaling. Deeply grateful to Arnab Mukhopadhyay for his mentorship!

Sabnam Rahman Arnab Mukhopadhyay Congratulations!

New Preprint alert🚨Vit B12 from microbiota has profound effects on life history traits, including longevity, through a methionine cycle → mitophagy axis. RICTOR/mTORC2 restrains this axis to maintain normal lifespan. doi.org/10.1101/2025.0… #C. elegans #Aging #mTOR

Excited to see our manuscript out Nature Communications pubmed.ncbi.nlm.nih.gov/40721431/. We identified that the 18S rRNA methylase DIMT-1 regulates lifespan by functioning in the germline after midlife. 1/8

Excited to share our work in Nature Communications! 🎉We discovered how ribosomes control aging: dimt-1-mediated rRNA methylation fine-tunes translation of longevity factors in C. elegans, linking ribosome heterogeneity to lifespan. Eric Greer Lab Hafiz Rothi 🔗nature.com/articles/s4146…

Excited to share our new work on transgenerational adaptation science.org/doi/epdf/10.11… out today spearheaded by outstanding former undergraduate Kathleen Kim NOT C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content,+ longevity 1/9