Independent reproducibility studies are the scientifically rigorous way to validate and compare the discriminatory value of biomarkers frontiersin.org/articles/10.33…

New Research: External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition: Immune checkpoint inhibitors have revolutionized treatment of advanced melanoma, but commonly cause serious immune-mediated… frontiersin.org/articles/10.33… #immunology

Proud to be part of cutting-edge research about how LCN-2 facilitates neuroinflammation and promotes brain metastasis. doi.org/10.1038/s43018…

Our article about dataset restriction is finally accessible as #preprint on Research Square : researchsquare.com/article/rs-292… 🥳🥳

Health implies homeostasis, whereas disease means dysregulation. It shouldn’t surprise us that disease markers are often more variably expressed in patients than controls Extra Horizon INsTRuCT Gunther Glehr Paloma Riquelme #melanoma #irAE

Our new paper in Nat Comms tackles the special challenge of unequal variability between classes for immune biomarker discovery and interpretation. We introduce Dataset Restriction as a solution that can be extended to any classification task. nature.com/articles/s4146…

Restriction is a procedure that splits datasets into classifiable and unclassifiable samples to define a biomarker’s informative and uninformative ranges.

Applying restriction as a pre-processing step typically improves the performance of multivariate models.

Restriction also helps with intraclass heterogeneity. An unanticipated consequence of restriction is that disease biomarkers with a bimodal distribution in the positive class, such as might arise from multiple aetiologies, are findable. #biomarkers #predictive_models #ROC_curve