This was an excellent state-of-the-art meeting focused solely on GPRC5d in #MMSM with some great presentations, debates, and exchange of ideas b/w Rahul Banerjee, MD, FACP Saad Z. Usmani MD MBA FACP 🇺🇸🇵🇰 Francesco Maura Binod Dhakal Joshua Richter, MD, FACP Sridevi Rajeeve, MD & others VJHemOnc

Thank you for the great submission process and beautiful cover art! Link to tweetorial here: x.com/FrancescoMaura…

Wonderful graphical art of our work investigating the mutagenic impact of radiotherapy in hematological malignancies. Memorial Sloan Kettering Cancer Center Moffitt Cancer Center Sylvester Comprehensive Cancer Center! Thanks Blood Cancer Discovery for the great editorial support!

Francesco Maura Nature Genetics Heidelberg Myeloma Sylvester Comprehensive Cancer Center Mayo Clinic Memorial Sloan Kettering Cancer Center MSK Department of Medicine We would like to inform you that your post has been published on OncoDaily. Thank you for sharing. oncodaily.com/insight/353651

#Myeloma Paper of the Day: Immune-MRD status informs tumor-MRD outcome prognostication in myeloma pts on Len maintenance; T cell profiles enriched w/ activated cytotoxic effectors predict early relapse & quiescent/naïve T-cells predicting remission: pubmed.ncbi.nlm.nih.gov/40853874/. #mmsm

Not all MRD resurgent pts are the same; some have 'immune' MRD negativity (naive PB T cell phenotype) that predicts long term disease control without the need for change of therapy. Excellent work by Ross Firestone Memorial Sloan Kettering Cancer Center #MedTwitter #MMSM #ClinicalCancerResearch

#Myeloma Paper of the Day: Pre-treatment w/ iberdomide & dex in Vk*MYC mouse model reshapes bone marrow T cell compartment, promotes infiltration of naïve T cells, and generates 100% response rates & long survival in subjects with high tumor burden: pubmed.ncbi.nlm.nih.gov/40864972/. #mmsm

Researchers interrogated 580 whole-genome sequence samples from patients with large B cell #lymphoma, multiple myeloma, and myeloid neoplasms. Heidelberg Myeloma They identified the ID8 mutational signature only in relapsed disease. 🧬 bit.ly/4m0geWX | Blood Cancer Discovery

#Myeloma Paper of the Day: Study looking @ genomic antigen loss timing in myeloma treated w/ T-cell redirection finds biallelic loss driven by events after BCMA/GPRC5D CAR-T/TCE; in 752 NDMM pts 2.7% & 9%, respectively, had monoallelic inactivation: pubmed.ncbi.nlm.nih.gov/40906971/. #mmsm

Dr Paola Neri presented data that genetic antigen loss is a late event in myeloma #SOHO25. Now published in Blood Cancer Discovery doi.org/10.1158/2643-3… #MMsm #Immunotherapy Francesco Maura nizar jacques bahlis