Marcelo Di Carli Brigham and Women’s Cardiovascular Imaging Program Brigham & Women's CV Fellows Brigham and Women's Radiology Harvard Medical School Mass General Brigham

Worth the read: new Circulation series of 2-page statistical reviews for clinicians.

Inaugural article on summarizing results of time-to-event endpoints is now published.

Couldn't think of better people than Andrea Bellavia and Sabina Murphy to lead this effort.

TIMI Study Group

In patients with TGs >150 mg/dL and high CV risk, apoC-III inhibitor olezarsen reduced TG levels by ~50%.

Olezarsen also reduced apoB and non-HDL-C, markers of atherogenic risk.

Proud to be a part of this team.

Full paper now in NEJM.

TIMI Study Group Brian Bergmark

The🧠efficacy &🩸safety of 💊 #NOAC vs. #warfarin in underweight or obese pts w/ #AF remains uncertain.

👇🏽Now in Circulation, we leveraged COMBINE to perform an IPD M-A of pivotal NOAC vs. warfarin RCTs (>58k 👥) to examine 💊 effect across BMI & BW.

ahajournals.org/doi/10.1161/CI…

Natriuretic peptide (NP) concentrations are ⬇️ in obesity, despite obese pts having ⬆️ risk for HF.

💡What are the prognostic 📈 & Rx implications 💊 of the NP-obesity relationship for HF risk stratification?

Now from TIMI Study Group in @ESC_Journal

onlinelibrary.wiley.com/doi/10.1002/ej…

🌟 Unlock the Power of Cardiac Imaging and join us Jan 19-21, 2024. Hands down the best course to master the latest in cardiac imaging with expert insights, case studies, and interactive hands-on learning! #ACCFIT #ACCImaging #CVnuc #YesCCT #YesCMR

Invaluable lessons in learning, leadership & life…what an honour & privilege to be part of the Brigham cardiovascular imaging family❤️ Thank you to our esteemed faculty, technical staff, admin team, researchers & family for making it all happen, day in day out 🙏 Happy Holidays!

André Zimerman presented today at #AHA23 new long term safety data from Ebbinghaus srudy with #evolocumab on behalf of TIMI Study Group. André is a rising 🇧🇷 star, works in the 🇺🇸 and will surely make many more contributions along his career. #CardioTwitter #Cardiology #cardioEd

Now published in JACC Journals #JACCINT : large analysis from the VIVID Registry evaluating the effects of THV positioning in mitral ViV on post-procedural hemodynamics and complications.

Michael Nanna Yale Internal Medicine Yale Cardiology Mark D. Siegel icszmc

authors.elsevier.com/a/1i4wn_i2X-OU…

Does LDL-C lowering to <40 mg/dL impair cognition over the long term?

Today at #AHA23 we showed, for the first time, that evolocumab + statin did NOT affect cognition up to *7.2 years*, despite LDL-C levels ~35 mg/dL.

Once again, very low LDL-C appears safe over the long term.

Late-breaking sessions and all with this crew at #AHA2023 !

TIMI Study Group

Well said, as usual, by Robert W. Yeh MD. Perfusion PET with myocardial blood flow will continue to grow in importance to patients, interventionalists, and general cardiologists. Marcelo Di Carli Venk Murthy MD PhD

Check out our new review of the data for an association between Lp(a) and platelet function.

UC San Diego Cardiology UC San Diego Cardiology Fellows UC San Diego Health

nature.com/articles/s4156…

No surprises but exciting to see Eli Lilly's tirzepatide break into obesity market with FDA approval - endpts.com/eli-lillys-tir…

🧪 Lp(a) has been hypothesized to exert a pro-thrombotic effect.

💡 In a secondary prevention population, do those with ⬆️ Lp(a) derive greater benefit from prolonged DAPT with ticagrelor?

Now in JACC Journals from TIMI Study Group Michelle O'Donoghue 👇

jacc.org/doi/10.1016/j.…

Presented my cardiac sarcoidosis research at #asnc2023 #brighamandwomenshospital #cardiovascularimaging Thanks to my mentors for making our long days meaningful for patient care, for the advancement of our field and more! Marcelo Di Carli Sanjay Divakaran Ron Blankstein Sharmila Dorbala

Great read highlighting Svetlana Mojsov’s largely unrecognized but pivotal contributions in the discovery of GLP-1. #obesity
| Science | AAAS science.org/content/articl…

Wonderful experience crafting this editorial on HF cardiogenic shock and PA catheters under the guidance of Dr. Lynne Stevenson and
Christopher O'Connor!
authors.elsevier.com/a/1hWwl3pkRzdp……

It’s been a little over a month now from my first ever publication and I couldn’t thank my mentors Filipe A Moura, MD, PhD, Rhanderson Cardoso and the other co-authors enough for this great achievement!!