A big mystery solved? Endogenous function of the CRBN Ligase revealed by Christina Woo et al nature!! Spoiler…it’s all about protein quality control. CRBN recognizes damaged proteins with cyclic di-peptides that mimic IMiDs! So cool👏👏 nature.com/articles/s4158…

An expanded Lexicon for the Ubiquitin code by @idikic IBC2 & Brenda Schulman Max Planck Institute of Biochemistry (MPIB) 😳 New types of #Ubiquitin modifications on serine, threonine, lipids, sugars, also on ADPR..opportunities for innovative #therapeutics nature.com/articles/s4158… rdcu.be/cYfBR

Wow!!! Congratulations Nurix Therapeutics for having achieved a complete (!) response in a patient with aggressive Non-Hodgkin's Lymphoma using their using a small molecule degrader. So wonderful to see these clinical data emerge with targeted protein degradation! ir.nurixtx.com/news-releases/…

#cIAP1-based %degraders induce #degradation via branched #ubiquitin architectures | Nature Chemical Biology nature.com/articles/s4158…

Paper free to read in Nature Chemical Biology: rdcu.be/cYUib. doi.org/10.1038/s41589…

Well done Tamer for an excellent PhD confirmation seminar today WEHI (Walter and Eliza Hall Institute) #PhDconfirmed #phdlife

Excellent #PhD confirmation seminar today by Philipp WEHI (Walter and Eliza Hall Institute) well done!

Feltham Lab Christmas Shenanigans @archiebrothers, great afternoon of arcade game fun 😁 #festiveseason #MerryChristmas

Feltham Lab Christmas Shenanigans continued @CargoRestaurant with our end of year awards. The best mistake award this year going to Bekky Feltham #MerryChristmas

WEHI researcher Dr Bekky Feltham was always intrigued by biochemistry. These days Dr Feltham heads up a #UbiquitinSignalling laboratory searching for new therapies to treat #InflammatoryDiseases Discover more in the new edition of Illuminate wehi.edu.au/news/illuminat…

The Vervoort and Feltham Lab Bekky Feltham are looking for an enthusiastic Research Assistant who wants to join our labs for a year to kickstart an exciting new project on degron therapeutics in cancer. Check it out and please share: wehi.wd3.myworkdayjobs.com/en-US/WEHI/job…

Well done Anna Gabrielyan for a fantastic talk for Australasian Cell Death Society WEHI (Walter and Eliza Hall Institute) today. Great story and really interesting data 🤓😎

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Great talk from jake today talking all things E3 ligase, a favourite topic in the Feltham Lab WEHI (Walter and Eliza Hall Institute)

Abstract submissions for 2024 @LorneProteins, incl. the Satellite Meeting on "Ubiquitin signalling: Molecular mechanisms, biology and targeted protein degradation" are closing soon. If you work on #ubiquitin, ubiquitin-like modifiers, #PROTACs or #TPD, we want to hear from you!

Unlocking the secrets of the E3 ligase MIB2!🕵🏻‍♂️ Our new paper PNAS Nexus unravels the mysteries of MIB2 in mice with the cpd mutation, and its unexpected role in wound healing 🐁🩹 An excellent study we're thrilled to share!#wehiresearch #MIB2Discovery academic.oup.com/pnasnexus/arti…

🔬2024 Lab Update! 🌟 Farewell to incredible team members, @DanielSimpsonAU and Anna Gabrielyan. Wishing them success as postdocs!💙Excited for new faces and opportunities in 2024. Here's to innovation, collaboration and new discoveries🚀 #LabLife #NewBeginnings #Science2024

Excited to be part of the CeTPD scientific opening #TPDFocus University of Dundee

Had an exciting morning of #TargetedProteinDegradation at the launch of Ternarx! Ternarx Fantastic to have strong support from Mark Butler MP and the incredible team WEHI (Walter and Eliza Hall Institute). 🔗 Explore our journey and vision: [WEHI Announcement](wehi.edu.au/news/wehi-spin…)

Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia. Late abstracts are still being accepted—worth checking out!!! 🦘🦘🦘