IDH inhibition in gliomas: from preclinical models to clinical trials nature.com/articles/s4158…

Thymoma, type AB An admixture of spindle cell and B1-like areas make this thymoma, which has numerous TdT-positive cells and may express CD20 in epithelial cells In portuguese: A - fusocelulAr #pathtwitter

Temporal artery Pictures are full of giant clues! What is the diagnosis? #pathtwitter

Striking nuclear atypia and "glassy" cytoplasm in this soft tissue tumor with WT1 expression - always gratifying to make this diagnosis given its good prognosis. #BSTpath

Accurate and comprehensive evaluation of O6-methylguanine-DNA methyltransferase promoter methylation by nanopore sequencing #neuropath onlinelibrary.wiley.com/doi/10.1111/na…

Methylation Case of the Week: 47 years old male patient with a left temporal mass. Glial markers are negative on IHC. High mitotic rate and necrosis are present. Hint: Some CNS sarcomas do not show a FasCICular arrangement. #pathology #Pathtwitter #neuropath

The best companies I can have! Gerônimo Jr. Jerad Gardner, MD Brazilian Congress of Pathology

Methylation Case of the Week: 24 year old male patient with a spinal canal, thoracic level T10-11, intradural-extramedullary tumor. EMA and PR are positive. Take a look and you'll be able to CLEARly see the diagnosis. Any thoughts? #Neuropath #Pathtwitter #Pathology

Atrx loss as a promising screening tool for the identification of diffuse midline glioma subtype, H3K27/MAPKinase co-altered #neuropath actaneurocomms.biomedcentral.com/articles/10.11…

Dedifferentiated liposarcoma with SFT-like morphology and STAT6 expression #BSTpath (PMIDs: 24457460, 37366085)

Temporal lobe tumor in a young adult with seizures. Diagnosis? Most likely mutation? (Don't GANG up on me with your guesses.) #pathology #neuropath #PathTwitter

If the polyp smiles back at you, you know it's an SSL/SSP (sessile smiling lesion). #GIpath 😀

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors #neuropath actaneurocomms.biomedcentral.com/articles/10.11…

Dura-based tumor in an adult. Diagnosis? What mutation might this tumor contain? (It's not a SECRET.) #pathology #neuropath #PathTwitter

Diffuse, IDH-wildtype gliomas in adults with minimal histological change and isolated TERT promoter mutation: not simply CNS WHO grade 4 #neuropath link.springer.com/article/10.100…

For those that had to miss the NIH DNA methylation meeting today. Thanks to Felipe D'Almeida for the share. modernpathology.org/article/S0893-…

Methylation Case of the Week: 5 year old male patient with a cervical spinal cord tumor, with evidence of spread across the neuroaxis. Tumor expresses glial markers and Synaptophysin. A fusion was found. A DiLiGeNT look at the case will clarify the diagnosis. #PathTwitter

FGFR1 wild-type rosette-forming glioneuronal tumours #neuropath link.springer.com/article/10.100…