Researchers at Shenzhen University reviewed how SARS-CoV-2 blocks autophagy and hijacks dual-function cytokines like IL-6 and IFN-γ, turning them from regulators into storm amplifiers. Restoring autophagy may help rebalance immunity. link.springer.com/article/10.100…

MECFS / PrecisionLife / Il- 6 / Estradiol I don't usually miss papers by this group...I guess I did or I forgot! The researchers found that ME/CFS patients had exaggerated immune responses after microbial stimulation, shown by higher production of IL-6 and other

"SARS-CoV-2 disrupts the choroid plexus (ChP; a network of capillaries and ependymal cells in the brain's ventricles) epithelium by binding to the ACE-2 receptor, causing blood cerebrospinal fluid barrier leakage and permitting interleukin (IL)-6 and pathogens into the brain,

Long COVID may be fueled by inflammation and tiny clots sciencedaily.com/releases/2026/…

Stellenbosch University researchers propose that viral infections like SARS-CoV-2 can trigger long COVID and ME/CFS by causing long-term endothelial senescence, disrupting blood flow and immunity and leading to chronic, multisystem symptoms. nature.com/articles/s4141…

More cute pics to fool the algorithm!

Muscle Health / MECFS This finding corroborates our concept of sodium and consecutive calcium overload as cause of muscular and mitochondrial damage caused by enhanced proton‐sodium exchange due to anaerobic metabolism and diminished activity of the sodium‐potassium‐ATPase. The

🚨 New state-of-the-art review on #POTS from an international multidisciplinary group of specialists. Thanks Dennis H Lau for inviting me to join: it's an honor! #MedTwitter #NeuroTwitter #BrainHealth #NeurologyProud #MedEd sciencedirect.com/science/articl…

High incidence of post-discharge cardiovascular mortality after COVID-19 hospitalization: a data... - goo.gl/scholar/ieypyL #ScholarAlerts

The Protective Role of Curcumin in Osteoarthritis: Establishing Mitochondrial Homeostasis... - goo.gl/scholar/zumLFd #ScholarAlerts

Dairy / Extracellular Vesicles / Gut Microbiome / SCFA / Liver Ibjury Gut microbiota analysis revealed that mEVs notably enriched the relative abundances of Faecalibaculum and Lactobacillus, which correlated positively with mEV-enhanced colonic short-chain fatty acid

Extracellular vesicles carrying miRNA may be cause of post-surgical cognitive dysfunction! Surgical and anesthetic rewiring of the glymphatic system in postoperative cognitive dysfunction - goo.gl/scholar/CuZ7Ez #ScholarAlerts

Reactive Microglia / LPS / Glycolysis / Mitochondrial Dysfunction LPS treatment led to a significant reduction in mitochondrial mass (TOMM20), increase in mitochondria fragmentation. We observed that LPS increases the phosphorylation of DRP1, indicating enhanced mitochondrial

What do you call recovery of MECFS? Comments eelcome?

Extracellular Vesicles - the cells' secret messengers - Scientific version youtu.be/OQeRfaQkZCk?si…

Microplastics / Extracellular Vesicles / Environmental Toxins "MPs can modify the molecular cargo of EVs, which may result in alterations of cell signaling pathways. Understanding the interactions between MPs and EVs could provide important opportunities to comprehend their