Key point: SCORE-AI is generalizable across geographically different patient populations, EEG equipment, and recording settings. doi.org/10.1111/epi.18… #epilepsy #ilae #automaticEEGanalysis #normalvariants #routineEEG #sleep #AI #EEG ILAE @epilepsiajourn Wiley Neuro

Key point: Assessment of factors associated with DRE without considering specific #epilepsy syndrome subgroups underestimates diversity and leads to inaccurate findings. doi.org/10.1111/epi.18… #ilae #children #drugresistant #focalepilepsy ILAE @epilepsiajourn Wiley Neuro

Epilepsia New Articles - August 17, 2024 mailchi.mp/64cb7544d5ce/e… #epilepsy #ILAE ILAE @epilepsiajourn Wiley Neuro

Key point: Stimulated seizure onset zone and interictal discharges are nonredundant surrogate markers for the spSOZ. doi.org/10.1111/epi.18… #epilepsy #ilae #SEEG #corticalstimulation #epileptogeniczone #seizureonsetzone ILAE @epilepsiajourn Wiley Neuro

Key point: Neurosurgical lesioning of stimulation-negative HGM language sites is associated with poorer cognitive outcomes. doi.org/10.1111/epi.18… #epilepsy #ILAE #electricalstimulationmapping #epilepsysurgery #functionalbrainmapping #SEEG ILAE @epilepsiajourn Wiley Neuro

Key point: People with #epilepsy (PWE) involved in motor vehicle crashes (MVCs) had lower socioeconomic status and more comorbidities than non-PWE. onlinelibrary.wiley.com/doi/full/10.11… #ILAE #fatality #seizure #singlevehiclecrash #trafficaccident ILAE @epilepsiajourn Wiley Neuro

Key point: This conference report summarizes information on five investigational treatments in clinical development, for which at least preliminary efficacy data in individuals with #epilepsy are available. doi.org/10.1111/epi.18… #ILAE ILAE @epilepsiajourn Wiley Neuro

Epilepsia New Articles - August 24, 2024 mailchi.mp/4cdb0753f493/e… #epilepsy #ILAE ILAE @epilepsiajourn Wiley Neuro

Key point: Specific NREM sleep oscillatory and nonoscillatory brain activity features are altered by the epileptic network. doi.org/10.1111/epi.18… #epilepsy #ILAE #scalefree #sleeposcillations #sEEG #biomarkers ILAE @epilepsiajourn Wiley Neuro

Key point: High-frequency features do not provide any additional value to the results of standard low-frequency #EEG analysis. doi.org/10.1111/epi.18… #epilepsy #ilae #HFOs #interictalepileptoformdischarges #machinelearning ILAE @epilepsiajourn Wiley Neuro

Key point: Genetic epilepsy caused by channelopathies is correlated with better seizure freedom outcomes in children treated with the ketogenic diet. doi.org/10.1111/epi.18… #epilepsy #ILAE #drugresistantepilepsy #etiology #ketogenicdiet ILAE @epilepsiajourn Wiley Neuro

Key point: Confirmatory factor analysis enabled refinement #CDKL5 Clinical Severity Assessments doi.org/10.1111/epi.18… #epilepsy #ILAE #clinicaloutcomeassessment #confirmatoryfactoranalysis #DEE #reliability #validity ILAE @epilepsiajourn Wiley Neuro

Key point: This study reports on vaccine recipients and unvaccinated participants in the pooled analyses of >26 million subjects in cohort studies. doi.org/10.1111/epi.18… #epilepsy #ILAE #COVID19 #safety #SARSCoV2 #vaccines #seizure ILAE @epilepsiajourn Wiley Neuro

Key point: After oxygen–glucose deprivation, #NKCC1 contributes to neuronal [Cl−]i elevation, depolarizing actions of GABA, and delayed onset of epileptiform discharges. doi.org/10.1111/epi.18… #epilepsy #bumetanide #hypoxiaischemia #phenobarbital ILAE Wiley Neuro

Key point: Triple-drug therapy may be a valuable preclinical strategy for screening investigational compounds for DS. doi.org/10.1111/epi.18… #epilepsy #antiseizuredrugs #Dravetsyndrome #pharmacokinetics #tripledrugtherapy ILAE @epilepsiajourn Wiley Neuro

Epilepsia New Articles - August 31, 2024 mailchi.mp/fdaac13dbe83/e… #epilepsy ILAE @epilepsiajourn Wiley Neuro

Introduction of the incoming Editor-in-Chief of Epilepsia Fernando Cendes onlinelibrary.wiley.com/doi/full/10.11… #epilepsy #editorinchief ILAE @epilepsiajourn Wiley Neuro

Pharmacological management of prolonged seizures in Dravet syndrome including intravenous phenytoin doi.org/10.1111/epi.18… #epilepsy #Dravetsyndrome #phenytoin #rescuedrugs #statusepilepticus ILAE @epilepsiajourn Wiley Neuro

Key point: This study examines the association between febrile #seizures and #epilepsy and subsequent risk of psychiatric symptoms in children 11 years of age. doi.org/10.1111/epi.18… #epidemiology #neurodevelopmentaldisorders #statistics ILAE @epilepsiajourn Wiley Neuro

Key point: Deficits in olfaction are commonly observed in ASD. doi.org/10.1111/epi.18… #epilepsy #autism #behavior #developmental #kainicacid #odor ILAE @epilepsiajourn Wiley Neuro