Hey Arizona Basketball, Now we are and our runway is clear for takeoff! 🛫⛅️

🫀🧑‍🔬💪Really excited to share that my first *cardiac* research project was accepted to Circulation Research! We study relaxed permeabilized papillary muscles before and after rapid 50% I-band titin cleavage with TEV protease. Below are the major findings.

So excited to share this work is now published in Nature Communications. It was great to work with Anthony Hessel, PhD throughout the process, and I look forward to sharing MyBP-C cleavage structural changes in active skeletal muscle in the next one!

Just wrapping up an amazing few days with the Samantha Harris lab! A little celebration of our new Nat Comm paper but already scheming for the bombshell follow-up paper being prepared by Nichlas M Engels. See you all at the myofilament meeting!

Scientists including Drs. Anthony Hessel, PhD, Nichlas M Engels, & Samantha Harris reported that myosin-binding protein C regulates the #sarcomere lattice and stabilizes the OFF states of #myosin heads. 👉 go.nature.com/3TVvr0J

Great visit with Anthony Hessel, PhD! Such a great scientist and colleague!

Muscle Cell News Nichlas M Engels Samantha Harris Also Michel Kühn and Dr. Weikang Ma at the BioCAT beamline, Advanced Photon Source Argonne National Lab

This bike lock is/was available for sale on campus via Columbia's Public Safety department under their "Crime Prevention Discount Bike, Locker and Laptop Lock Program". See their flier with a discount here: publicsafety.columbia.edu/sites/default/…

This is how great science is made, by 75% Chinese rockets fuel Anthony Hessel, PhD Michel Kühn Nichlas M Engels Vivek Jani

Researchers led by Dr. Anthony Hessel, PhD reported that fast myosin binding protein C knockout in #SkeletalMuscle 💪 alters length-dependent activation and myofilament structure. 📍 Communications Biology | go.nature.com/3KlbGKk

Assistant Professor Weikang Ma pushes the boundaries of science, searching for ways to protect the heart against inherited cardiac diseases. Having received a $2 million grant from NIH, Ma’s research is on the path to a new frontier. Discover Ma's impact:bit.ly/49L7Bd0

T-0.5 days until our Xray beamrun. Build day! Long day of vpreparing. Tomorrow is showtime!

And we are three days in! So many pappilary muscles. Progress ok! Now a quick shower, pack a bag, prep a few more samples, and then straight to the plane for the Hamburg run at DESY (Deutsch)! See you soon Michel Kühn!

Day 10/11. Heavy lifting back at NSLSII at BNL. Some hiccups on the way: RIP special ABs at Newark customs. But lots of success on several other projects! Khoi D. Nguyen, Nichlas M Engels, Rachel Sadler, and Brad Palmer Crew working at max capacity! Final 40 hour push starts now.

Day 12, 230am. It is Finished! We are out of samples! The monster beamline run is over! What a ride! So many things accomplished over 2 continents and beamlines. Mouse hearts, human hearts, various skeletal muscles, cardiac strips, zebra fish, MARP proteins...214 hours of work.

Nichlas M Engels, We are excited to see your presentation! You are making #MyBPC famous! UArizona Dept of Cellular & Molecular Medicine UArizona Sarver Heart Center University of Arizona Health Sciences BIO5 Institute

Nichlas M Engels puts in the big effort at Advanced Photon Source Argonne National Lab and NSLSII Brookhaven Lab during monster data collection runs. Head down / stay positive. He w/ Samantha Harris lab are uncovering the roll of MyBPC to the regulation of force production. Loads more projects incoming!

Huge beamrun over at LiX beamline, NSLS II Brookhaven Lab. Last 96 hours with veterterans Nichlas M Engels / Rachel Sadler, Christine Delligatti Christine Delligatti, and the brilliant Khoi D. Nguyen.

As #BPS2025 nears, we wanted to highlight a recent publication in biophysics! 🔬 Anthony Hessel, PhD et al. investigated the role of MyBP-C in muscle 💪contraction and regulation with small-angle X-ray diffraction and #AuroraScientific 1600A system. doi.org/10.1038/s41467…

It was very nice to welcome our muscle users Anthony Hessel, PhD Michel Kühn Vivek Jani back after two years for Advanced Photon Source upgrade. BioCAT remains the state-of-art facility for muscle X-ray diffraction. Proposal for next run due in two days!