We are seeking motivated Postdoctoral Fellows passionate about cell signaling. Join us at UC San Francisco to harness the power of cryo-EM and proteomics to study Receptor Kinase signalosomes. More info about our lab at cvri.ucsf.edu/~jura/ Please RT!

Congratulations Roshanak!! Terrific news! 🥳🥳🥳🎉🎉🎉🎉

Happy to share our new chemogenetic system CATKLAMP to activate TREK channels irreversibly, probe fundamental channel mechanisms, and turn off neurons. Great work from team Chemogenetic K2P🎉🎉 Parker Deal Abhisek Mondal Marco Lolicato @IsacoffLab Adam Renslo biorxiv.org/content/10.110…

Congratulations to Stephen and this nanobody team. Exciting findings highlighting the P1-M4 interface innK2Ps.

Minor lab Halloween fun. Super good looking 😀

A huge thanks to @eperozo for the invite to The University of Chicago BMB. Fantastic day. Terrific students (showing up for a 9:30 AM seminar. It is a serious place 😀!) and lots of fun discussions with the BMB faculty. A real pleasure!

Thanks to Manu for the invite to CUMC Physiology. Fantastic day to see old friends, meet new ones, and hear about all of the exciting research. 🙏

A great lab tradition ⁦Biophysical Society⁩ Dinner with multiple generations of talented lab members. 🙏. First up tomorrow is ⁦Zhou Chen⁩ with a flash talk and poster on out EMC:Cav chaperone:channel complex.

Masterful flash talk by ⁦Zhou Chen⁩ 🙌on our work unveiling the first structure of an ion channel assembly intermediate and first example of a ion channel:chaperone complex. Come to his poster B381 ⁦Biophysical Society⁩ 2024 this afternoon.

Great presentation by ⁦Abhisek Mondal⁩ on our work on defining the gabapentin binding site on calcium channels. Come to poster B381 ⁦Biophysical Society⁩ later this morning for discussion of his work.

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies biorxiv.org/content/10.110…

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site biorxiv.org/content/10.110… New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from Stephen J. Tucker

Big day for THIK-1 channels!

Congratulations to Minor lab SF IRACDA postdoc Dania Zuniga on work from her PhD studies. 🥳👏 Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome. biorxiv.org/content/10.110…

Day 3 of #GRC #IonChannels is off & running. Prof. Kenton Swartz NIH kicks things off w/ Prof Dan Minor Dan Minor talking on "#Electrosomes: Some Assembly Required" #ephys #electrophysiology #patchclamp #structurefunction #cryoEM

Auguri a mia amica cara Anna Moroni on being elected as an EMBO Fellow Moroni's Lab 🥂🥂🎉🎉🥳🥳🥳 So well deserved for many great contributions to understanding ion channels ❤️ Super happy for you!! people.embo.org/profile/anna-m…

Our CATKLAMP system to control cell excitability with a covalently activated potassium channel is out.🍾🍾 Got a nail for this hammer? We want to test it in other systems. Development of covalent chemogenetic K2P channel activators: Cell Chemical Biology cell.com/cell-chemical-…

Congratulations to Parker Deal Abhisek Mondal Adam Renslo @IsacoffLab [email protected] Marco Lolicato and the whole CATKLAMP team !! cell.com/cell-chemical-…

Our newest rouges' gallery of saxitoxin congener structures with the High Himalaya frog saxiphilin. 🙏to Sandra Z, Dr Samantha Nixon, and Zhou Chen and our awesome collaborators DuboisLab Marta Filizola NOAA's Ocean Service biorxiv.org/content/10.110…

Find me @electrosomeucsf.bsky.social