Will be presenting the ‘Safety and effectiveness of PFA for A Fib in patients with HF’ A MANIFEST-PF registry sub-analysis’ at the LBCT Heart Rhythm Society meeting! Vivek Y. Reddy Mount Sinai Fuster Heart Hospital Mount Sinai Health System

#EPeeps Join us this Friday starting @ 12pm for @connectEP Session LXII: Pulsed Field Ablation for Atrial Fibrillation: ADVENT & MANIFEST 10K+ featuring Vivek Y. Reddy Emmanuel Ekanem Moussa Mansour David Haines, Pierre Jaïs, Francis Marchlinski. Register @ epconnect.live/PFAsession

MANIFEST-17K study is the largest registry of PFA to date: 17,642 pts/ 106 sites.
-Major complication rate of 1%- No AE fistula/PV stenosis
-Coronary spasms were rare but can be associated with VF
-Previously unreported AE-Hemolysis with renal failure (0.03%)

Our study, MANIFEST-17K, will be presented this morning at #AHA23 as a Featured Science Abstract! Assessed the safety of post approval PFA with a pentaspline catheter in treating >17, 000 pts with AF.
Stay tuned for the results.
#MANIFEST -17kConsortium
Vivek Y. Reddy AHA Science

After a few months with the Biosense Webster QDOT ablation catheter.. thus far a great addition to the therapeutic armamentarium

-🤔 “super” high power (90 watts) -catheter-tissue interface heat map
-modulated catheter tip irrigation

Pretty cool tech!

Mount Sinai Fuster Heart Hospital

122 electrodes on a 33 mm spherical array> mapping/pacing/PFA from customizable ablation elements around the “globe”.
First series of patients in the US as part of the PULSAR clinical study which aims to enroll >400 patients world wide.
Vivek Y. Reddy @mohitkturagam Kardium

122 electrodes on a 33 mm spherical array> mapping/pacing/PFA from customizable ablation elements around the “globe”.
First series of patients in the US as part of the PULSAR clinical study which aims to enroll >400 patients world wide.
Vivek Y. Reddy @mohitkturagam Kardium

Safety and Effectiveness of #PFA to Treat #AF : 1-yr Outcomes From the MANIFEST-PF Registry ⁦Vivek Y. Reddy⁩ ⁦Serge Boveda⁩ ⁦Roland Tilz⁩ ⁦Andreas Metzner⁩ ⁦Thomas Deneke⁩ ⁦Daniel Scherr⁩ ⁦BostonSci Cardiology⁩ ⁦⁦ ahajournals.org/doi/abs/10.116…

..And we are off! First case in the AdvantageAF study-A Prospective Single Arm Study of the @farapulse PFA System in pts with persistent AF. Goal to enroll ~417 pts. Look forward to the results and impact on the management of AF. Vivek Y. Reddy @mohitkturagam BostonSci Cardiology

The 2023 Atrial Fibrillation Symposium was truly a fantastic conference! Late breaking clinical trials, ground breaking advances, second generation PFA! I commend the organizers for a great conference!
#AFsymposium2023 #EP #healthcareinnovation

Our follow up study was recently presented as late breaking trial at ESC 2022. MANIFEST-PF study is the largest real world registry evaluating the safety and clinical efficacy of PFA! European Society of Cardiology Vivek Y. Reddy @mohitkturagam Andreas Metzner Serge Boveda Thomas Deneke Roland Tilz

Real-world use of the FARAPULSE™ PFA System (MANIFEST-PF): Retrospective multi-national survey of over 1700 patients. See the publication here: bit.ly/3zDZ50l

Caution: Investigational Device. Limited by US law to investigational use only. Not available for sale.

A privilege to recognize the Cardiology Fellows at their graduation dinner . Hooman to Hopkins ( Interventional), Lenny to Tufts (HF), Emanuel returns from Sinai (EP) to share the value of Inova training. Congrats to all faculty and fellows . Well done !

Our study, MANIFEST-PF recent late breaking at EHRA, is now available in this issue of Europace! Largest (n=1758 pts) real world registry of PFA! doi.org/10.1093/europa… Vivek Y. Reddy @mohitkturagam Andreas Metzner Philipp Sommer Serge Boveda Thomas Deneke Roland Tilz

Our work on interatrial block just presented at #HRS2022 by Joshua Lampert, MD

We studied 1,068,694 patients across 5 centers examining IAB outcomes (in AF and non-AF👥)

🔑finding
IAB associated with a 49% increased adj risk of stroke in patients without AFib

Ben Glicksberg lab

Cardiac Anatomy Before & After McAlpine - Tung, Shivkumar, Garcia_ Standing Room Only Roderick Tung BIOTRONIK US Kalyanam Shivkumar MD PhD

Vivek Y. Reddy at #EHRA2022 Late Breaking Trial Session: Manifest-PF registry with >1700 PFA procedures analyzed with @farapulse Boston Scientific.

Our study just presented at #EHRA2022 as late breaking clinical trial: MANIFEST-PF study largest (n=1758 pts) real world registry of PFA! Published European Society of Cardiology Journals #MANIFEST -cooperative Vivek Y. Reddy @mohitkturagam Andreas Metzner Philipp Sommer Serge Boveda Thomas Deneke Roland Tilz

Great experience participating in live case today demonstrating VoM infusion strategy for persistent AF ablation. Previously shown to improve freedom from AF/AT/AFL and acute success and durability of mitral block. #AFSymposium2022 Vivek Y. Reddy @mohitkturagam Mount Sinai Fuster Heart Hospital

Excellent talks and innovative research and technology is on display during the ongoing #AFsymposium Vivek Y. Reddy Moussa Mansour Looking forward to participating in live case today @ 11pm! Tune in!