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"Actually the term 'doctor' was originally used for doctoral degree holders and was co-opted by the medical field"

A Critical View on the Use of DNA Hydrogels in Cell-Free Protein Synthesis (Christof M. Niemeyer and co-workers) Niemeyer-Lab #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…

The annual @RSC_CBBG Forum is being held in Bristol next February! This is fantastic opportunity for new group leaders and postdocs in #chembio to talk about their science - oral abstract deadline is 6th December!!!

Excited to be at Biochemical Society Synthetic Biology UK 2024 #SBUK24 at the Sanger Institute near Cambridge! Going to give a little talk about our magnetic activation work 😊 will be posting on the bluer place... #biochemevent

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by Disha Kashyap Tom Milne Chemistry in Cells Oxford Chemistry UCL Chemistry chemrxiv.org/engage/chemrxi…

Really cool design: sending ASO to nucleus via conjugating JQ1.

#Phd project available to join my group and Michael Booth's group at UCL Chemistry on the #CDT in #Engineering Solutions for #Antimicrobial #Resistance to work on electrokinetic and nucleic acid technology for lateral flow assays (ucl.ac.uk/london-nano/cd…) App Deadline: 26/01/25

Super congratulations! 👍👍👍

Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enhances their activities by enhancing nuclear penetration.

JQ1 4EVA! Jay Bradner, M.D. Jun Qi Lab

#ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-recruitment of antisense oligonucleotides🧬 One of my main DPhil projects #RNAtherapeutics! Michael Booth Tom Milne Chemistry in Cells Oxford Chemistry MRC WIMM

Read our review on next-generation covalent modifications for nucleic acid therapeutics! 🧬💊

Still time to apply for this #PhD project to join my group and Michael Booth group at UCL Chemistry Project is part of #CDT in #Engineering Solutions for #Antimicrobial #Resistance App #Deadline: 26th Jan CDT #OpenDay : 14th Jan on Zoom More info 👉 shorturl.at/tmfBK

Massive congratulations to Prof Zoë Waller for winning the 2024 Royal Society of Chemistry Chemical Biology and Bioorganic Lectureship - today, giving her fantastic award lecture at the 2025 RSC CBBG Forum, in Bristol 🥳🏆

New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels! Last of Disha Kashyap's trilogy! Tom Milne chemrxiv.org/engage/chemrxi…

We have engineered lysosomal trafficking-ASOs (LyTONs)! Novel mechanism of gene knockdown🧬 LyTONs don’t need RNase H recruitment — work as well/better than state-of-the-art gapmers! #RNAtherapeutics Michael Booth Tom Milne Chemistry in Cells Oxford Chemistry MRC WIMM

We’ve integrated DNA nanotech into targeted protein degradation! Our oligoPROTACs act like small mol PROTACs but can be turned “OFF” — exciting alternative to pro-drug based activation for reducing toxicity! Michael Booth Tom Milne Chemistry in Cells Oxford Chemistry MRC WIMM