Real world 🇬🇧 Lorlatinib study

🔹 2L mPFS = 5.0m
🔹 3L+ mPFS = 17.2m
🔹 3% developed CNS on treatment

Limited activity in 2L sobering. Perhaps 1L Lorlatinib, given CROWN data, becoming a more attractive option 🤔

Great work from Tylan Lucas & Daniel Hughes

#LCSM #BTOG24

NHS colleagues, please consider sharing & signing - ongoing access to this highly valuable mental health resource is critical to support the welfare of our NHS health care professionals ⬇️

The tumour microenvironment educates us in patient risk of metastasis/relapse in lung cancer… Charles Swanton NIHR UCLH Biomedical Research Centre The Crick #AACR24

#AACR24 date for your diary - I'll be sharing work in a fantastic collab btn eriksahailab Maini Lab UCL on liver metastasis in melanoma Wellcome The Crick Manchester Cancer Research Centre

Genomic dark matter and its role in accelerated aging, tumorigenesis and inflammation….

#AACR24

While we are at the #AACR24 our own Chloe Belland won the best poster award at the #EADO24 Congress in Paris #Uveal_melanoma Heather Shaw Paul Nathan Ben Shum Anne-Laure Cattin Husayn Pallikonda Camille Gérard #PEACE consortium Mariam Jamal-Hanjani

Heather Shaw delighted that heather will be part of a 1st class melanoma sess @UKOF 13&14 June BRIGHTON. FREE-Reg now oncology-forum.co.uk leading cancer experts,ASCO insights & much more! #UKOF24

A fab collaboration between Oxford and UCL/Crick. ⁦Charles Swanton⁩ ⁦Maise Al Bakir⁩ ⁦Kevin Litchfield⁩ Mariam Jamal-Hanjani⁩ discovered neoantigens, tim_tje⁩ designed vaccine, ⁦zinaida⁩ validated it ⁦for trial OCTO Oxford⁩ ox.ac.uk/news/2024-03-2…

Always the highlight of the #CCTU year! Don’t miss it 👇

Calling any haematology trainees that are interested in getting experience with cutting edge early phase clinical trials in myeloma, leukaemia and lymphoma.

Come and work with us, you’ll have fun and learn loads!

UCLH NIHR UCLH Biomedical Research Centre Jen O uclh.nhs.uk/work-with-us/c…
👇👇

I was overjoyed ❤️💙💚to share a stage with the amazing Heather Shaw. There was spontaneous applause when we heard what she was achieving in the #cancervaccine space! Carles Escriu, Anna Olsson-Brown Andrew Furness also showing UK cancer triumphs for the acp.org.Uk 🙂

You are (at least partly) what you eat… ;)

There is a common misconception that melanoma skin cancer doesn’t occur in people with black or darker skin tones. Acral Lentiginous melanomas are the most common form of melanoma in people with dark skin. But they can occur in ANY skin colour.

Info: buff.ly/3VQsJZr

My consultant colleague Tom running the marathon… do support him if you can (madness!!) :)

It's #ChildrensMentalHealthWeek .

When a parent/guardian of a child/adolescent is diagnosed with melanoma, it can cause a whole range of emotions for the family unit. Charlotte & her son Joshua, have written a blog about their experience of this.

Blog :buff.ly/4b6uo4H

New paper showing infection=biggest cause of CAR-T TRM, partic in patients with high-burden disease. Important message here also re ‘cold sepsis’ risk in patients on steroids +/- anakinra. Great work ⁦Maeve O'Reilly⁩ ⁦UCL Cancer Institute⁩ ⁦⁩ onlinelibrary.wiley.com/doi/10.1002/he…

Some news coverage of our CAcTUS trial using ctdna to decide when to switch treatment -shows what it means for patients - although the data is very early and still to be understood properly!
bbc.co.uk/news/uk-englan…

'GRAIL-Galleri: why the special treatment?', we ask in today's The Lancet as voices from the UK public health oncology community.

From Richard Sullivan Ajay Aggarwal Houlston Lab, ICR
Paul Pharoah (R soul) 🇪🇺🇵🇬🇿🇦🇬🇧 Margaret McCartney Stuart Hogarth
Prof Nick Wald Clare Turnbull- Prof/NHS Dr

thelancet.com/journals/lance…

Really happy to see this study published and to be leading for the UK in the Phase 3 @UCLH :)
New ways to deliver concepts - and stellar HR so far for very little extra in the side effect profile.

Immuno-Oncology Clinical Network Dr Lennard Lee (Oxford University) Professor Sarah Danson MSD Melanoma Focus UK kylie gyertson

An excellent safety overview for pembro from a large series in multiple centres :)