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Ever since my PhD, working with biosensors has been an absolute thrill—there is nothing quite like witnessing real-time changes in living cells! I'm truly excited about the recent work by Jin Zhang Lab, which we had the pleasure of commenting on! Vikas Trivedi M. Madan Babu

A high-resolution deep mutational scan of MC4R reveals how thousands of genetic variants impact obesity-linked signaling pathways and highlights new opportunities for precision drug discovery Subscribe to the Dr. GPCR Newsletter today 📰 ➡️ buff.ly/FFSynZI  #gpcr#drgpcr

What do mission-driven teams and world-class science have in common? Integrity, systems that last, and the right people 😉In this episode, Joe & Chuck from Company Launch Partners share what it means to build something that endures. 🎧 buff.ly/u7XaZLU #gpcr #DrGPCR

To all the moms, mother figures, and supporters in our community, thank you for the care, laughter, and encouragement you bring to every part of life. Today, we celebrate you with hearts full of love. ♥️ Happy Mother’s Day! #MothersDay2025 #DrGPCR #GPCRCommunity

Disrupting VIPR2 dimerisation halts breast cancer spread—could TM3-4 peptides be the next breakthrough in targeted cancer therapy? Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ buff.ly/0XMSU1X #gpcr#drgpcr

🔍 Running a GPCR lab? Applying for grants? Launching a nonprofit? Ep.165 of the DrGPCR Podcast is your finance + operations crash course—delivered by two experts who support early-stage mission-driven teams like Dr. GPCR 🎧 buff.ly/u7XaZLU #gpcr #DrGPCR #ScienceTwitter

Can we preserve opioid pain relief without the side effects? On Ep.166 of the DrGPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment, with a 10x boost in methadone efficacy. 🎧 buff.ly/Kr3qKud

In Ep.166 of the DrGPCR Podcast, Ben Clements explains how classic pharmacological tools complement high-throughput technologies. From chronic pain models to neuroma-based insights, this episode bridges fundamentals with innovation. 🎙️buff.ly/Kr3qKud #DrGPCR #GPCR

🎧 Dr. Ben Clements dives into GPCR advancements + Check out our Store ♦️ New sweet receptor structure ♦️ Biased signaling in Class B GPCRs ♦️ mGluR2 activation by membranes ♦️ Novo's $2.2B deal with Septerna for obesity solutions Full Issue → bit.ly/4jVcBRP

By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor complexes. Check out the latest GPCR news today! ➡️ buff.ly/YVxpXeb #gpcr#drgpcr

In Boston this week for the GPCRs– Targeted Drug Discovery meeting? I’ll be at the Revere Hotel bar on Wednesday (May 22) at 6pm for a casual happy hour. GPCR folks in biotech, CROs, or VC welcome. DM if you want to join! #GPCR #Biotech #DrugDiscovery #DrGPCR

In Ep.166, hear how a postdoc is reshaping the conversation on opioid use, imposter syndrome, and the power of collaborative science. Why early-career voices are critical in GPCR drug discovery —and how lab culture makes all the difference 🎧 buff.ly/Kr3qKud #DrGPCR #GPCR

In Ep.166 of the DrGPCR Podcast, Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs. The catch? It’s all about understanding the system, not replacing it. 📲Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology

This week at #DrGPCR ♦️ New Course & Symposia recordings ♦️ Arrestin binds GPCRs w/o activation ♦️ G(z)ESTY assay finds ligands for orphan receptors ♦️ Triple-FRET reveals hidden GPCR state ♦️ Biagon, AbbVie & more drive AI drug discovery 👉 buff.ly/byfm2ny #GPCR #AI

How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Catch up on the latest GPCR News. Subscribe today! ➡️ Go to buff.ly/KCgaaQ2 #gpcr#drgpcr

What if you could map GPCR-RAMP interactions across all families in one experiment? Our guests made it happen! In Ep.167, we chat with Drs. Tom Sakmar & Ilana Kotliar about how their lab developed DUET-tag GPCRs, Luminex assays & online tools buff.ly/tS5lOjP #GPCR #DrGPCR

In Ep.167 of the DrGPCR Podcast, Tom Sakmar and Ilana Kotliar reveal a full GPCR-RAMP interaction map—powered by Luminex, dual-tagged constructs, and open science. Big win for the GPCR community. ✳️ Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCR #DrGPCR #ScienceTwitter

This week at Dr. GPCR: New course on non-canonical GPCRs + Podcast on 30 yrs of RAMPs. Highlights include arrestin signaling, lipid probes & non-opioid pain relief. ♦️ Phospho-barcodes, βarr2 bias, PI(4,5)P₂ tracking ♦️ Septerna, Maxion & Tectonic news 👉 buff.ly/qpqioQu

Class B GPCR drugs are reshaping treatment for migraine, diabetes, and obesity. This new review explores how tweaking peptide drugs can boost efficacy, reduce side effects, and unlock next-gen therapies ➡️ecosystem.drgpcr.com/reviews/where-… #gpcr#drgpcr

Autoantibodies that activate GPCRs? Wild, but real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling in Ep. 167 of the podcast. Are you thinking diagnostics? 📲Go to ecosystem.drgpcr.com/dr-gpcr-podcas… #GPCR #DrGPCR #ScienceTwitter