Domainex has successfully developed a #competition based spectral shift assay for ATP-competitive inhibitors for several #kinases. Read the full case study here: domainex.co.uk/drug-discovery… #SpectralShift #CompetitionAssay #AssayDevelopment

If you missed our poster, "Integral Membrane Proteins for Biophysics and Cryo-EM Applications - Case Study of the Ion Channel TrpML3" at the 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets, we have posted it here. #ionchannels

We have established assays for determining Kinact/Ki (for irreversible #covalent inhibitors) and for determining Kobs, maximum percentage of binding, and Koff rate (for reversible covalent inhibitors). Find out more: domainex.co.uk/services/kinac… domainex.co.uk/services/rever…

#Domainex are attending Drug Discovery Chemistry 2025 in San Diego next week (14th-18th April). Ray Boffey and Chris Miller will be there and are looking forward to discussing how Domainex can help advance your lead discovery programmes. Email [email protected] to meet.

In our latest blog, we have delved into two recent publications. The first describes the #synthesis, #characterisation, and evaluation of angular spirocyclic azetidines. The second describes a light-promoted aromatic denitrative chlorination reaction. domainex.co.uk/news/synthesis…

Domainex is delighted to welcome Nadine Myers to the assay biology team as a Senior Scientist I. Nadine recently completed her PhD in Biochemistry at Uppsala Universitet and has expertise in biophysical and structural biology techniques

Thanks to IPI Journal for publishing our article on #covalent inhibitors written by Andrew Ratcliffe and Scott Martin. international-pharma.com/covalent-drug-…… #DrugDiscovery

#Domainex can assess the Experimental Polar Surface Area (EPSA) of your compounds. The #EPSA assay is relatively fast and cost-effective compared to more complex in vitro or in vivo methods. Find out more: domainex.co.uk/services/exper…

Domainex would like to thank Prof Kevin Weeks from the University of North Carolina for visiting our site at Unity Campus last week and giving an excellent talk entitled "Principles of targeting RNA with small molecules" as part of our Science and Snack talks.

In our latest blog, we highlight a paper describing the discovery of a #CNS active GSK3 degrader using “orthogonally reactive linkers” and a direct-to-biology approach. lnkd.in/evTqarZi Find out more about #D2B by getting in touch with us via [email protected]

We’re pleased to share that we’ve just taken delivery of two MINI 96 liquid handlers from INTEGRA Biosciences! This exciting addition to our liquid handling capability will enable us to move even faster with our Direct-to-Biology projects. #D2B #Direct2Biology #DrugDiscovery

In our latest blog, we highlight work from GSK, in which they use a #D2B approach to drive optimisation of a cell-active covalent inhibitor of WRN helicase. domainex.co.uk/news/medicinal…

#Domainex is delighted to welcome Hayley French as our new CEO. Hayley is an accomplished attorney with a background in microbiology and significant experience in the life sciences sector. See the full press release here: domainex.co.uk/news/domainex-…

Did you know that Domainex offers a range of services ideal to support #biotherapeutic programmes? Find out more on our website: domainex.co.uk/services/bioth… #Biologics #StructuralBiology #Bioanalysis #Biophysics

If you are at the Cambridge Ion Channel Forum this Thursday, take a look at our poster on integral membrane proteins for #biophysics and cryo-EM. Natalie Winfield will be there. #Domainex #IonChannels #cryoEM #MembraneProteins

If you are at #PEGSBoston this week, take a look at our poster (A030) on integral membrane proteins for #biophysics and cryo-EM. Chris Miller will be there and is looking forward to discussing the poster, and the integrated drug discovery services that #Domainex can offer.

We are delighted that Sitryx Therapeutics has nominated SIT047, a novel, oral MTHFD2 inhibitor, for clinical development in psoriatic arthritis. It was our pleasure to have supported this project by providing an integrated team who worked collaboratively with Sitryx through the LO phase

Are you developing covalent inhibitors? Get in touch with #Domainex to find out how our GSH reactivity assay can help. We also offer a wide range of #ADME assays. Get in touch with us at [email protected] to find out more and ask us about our introductory discounts.

Have you got a molecular glue programme that you need support for? If so, get in touch with Domainex to find out how we can assist. Get more information on our website: lnkd.in/eN46zeCn or get in touch with us at: [email protected]

Two weeks to go until #Bio2025 Meet our new CEO Hayley French and catch up with Ray Boffey and Chris Miller at our booth on the UK Pavilion (Hall A, Stand 765) or get in touch to set up a meeting.