Dipesh Uprety MD FACP (@dipeshupretymd) 's Twitter Profile
Dipesh Uprety MD FACP

@dipeshupretymd

Assistant Prof | Thoracic Oncology 🫁 & Phase-I @karmanoscancer | EIC @BTFCancerNews | Previously @MayoCancerCare @gundersenhealth @JeffHealthAb | Tweets my own

ID: 1006712274747297792

linkhttps://www.karmanos.org/karmanos/karmanos-physician-directory/uprety-dipesh-10457 calendar_today13-06-2018 01:38:04

3,3K Tweet

1,1K Followers

837 Following

Dr. Antonio Calles 🫁🚭 (@tony_calles) 's Twitter Profile Photo

💥 The end of Pembro reign? Phase 3 Study of Ivonescimab (AK112) vs. Pembrolizumab as First-line Treatment for PD-L1-positive Advanced NSCLC: HARMONi-2 #WCLC24 #LCSM

💥 The end of Pembro reign? 
Phase 3 Study of Ivonescimab (AK112) vs. Pembrolizumab as First-line Treatment for PD-L1-positive Advanced NSCLC: HARMONi-2 #WCLC24 #LCSM
Jarushka Naidoo (@drjnaidoo) 's Twitter Profile Photo

#WCLC24 Presidential I Ph III HARMONI-2 ivonescimab v pembro in PDL>1% NSCLC: - 398pts - PFS HR 0.51 (11.1 v 5.82 mPFS) - benefit across histology & PDL1 🌟 Impressive data overall ❓Is this a step forward for PDL1 1-49% grp? 80% males enrolled, data needed in women IASLC

#WCLC24 Presidential I

Ph III HARMONI-2 ivonescimab v pembro in PDL>1% NSCLC:
- 398pts
- PFS HR 0.51 (11.1 v 5.82 mPFS)
- benefit across histology & PDL1 

🌟 Impressive data overall
❓Is this a step forward for PDL1 1-49% grp? 80% males enrolled, data needed in women <a href="/IASLC/">IASLC</a>
Rami Manochakian MD, FASCO 🇺🇸🇸🇾CancerEducation (@rmanochakian) 's Twitter Profile Photo

🔥🚨OncoAlert HOT OFF THE PRESS. Just presented at the presidential symposium IASLC #WCLC24 Results of #HARMONi2 trial of #Ivonescimab VS #Pembrolizumab in advanced non-small cell #LungCancer with PD-L1 >1%. ✅ Significant ⬆️mPFS 11.14 vs. 5.82 months (HR 0.51) #Benefit

🔥🚨<a href="/OncoAlert/">OncoAlert</a> HOT OFF THE PRESS.

Just presented at the presidential symposium <a href="/IASLC/">IASLC</a> #WCLC24 

Results of #HARMONi2 trial of 
#Ivonescimab VS #Pembrolizumab in advanced non-small cell #LungCancer with PD-L1 &gt;1%.

✅ Significant ⬆️mPFS
11.14 vs. 5.82 months (HR 0.51)

#Benefit
Stephen V Liu, MD (@stephenvliu) 's Twitter Profile Photo

ARTEMIS-001 results at #WCLC24. HS-20093 (B7-H3 ADC) in #SCLC with impressive efficacy. RR 50-61% and DCR 81-96% across two doses. DOR 6.4-8.9m. AES mostly hematologic. 8mg/kg dose seems more favorable. No link with B7H3 expression and efficacy. Phase 3 studies ongoing.

ARTEMIS-001 results at #WCLC24. HS-20093 (B7-H3 ADC) in #SCLC with impressive efficacy. RR 50-61% and DCR 81-96% across two doses. DOR 6.4-8.9m. AES mostly hematologic. 8mg/kg dose seems more favorable. No link with B7H3 expression and efficacy. Phase 3 studies ongoing.
Alberto Güijosa (@alberto_guijosa) 's Twitter Profile Photo

Thrilled to see my mentor Oscar Arrieta speak at the #WCLC2024 Opening Plenary Session! Truly honored to have been guided by someone who continues to inspire my research and clinical journey. Instituto Nacional de Cancerología #Mexico #LungCancer

IASLC (@iaslc) 's Twitter Profile Photo

Monday morning at #WCLC24: The second of two Presidential Symposia will showcase late-breaking abstracts on targeted therapies. Learn more from IASLC President Dr. Paul Van Schil in #ILCN: bit.ly/3Ze8hWb #LCSM

Stephen V Liu, MD (@stephenvliu) 's Twitter Profile Photo

Dr. Xiuning Le MD PhD presents data on BAY 2927088 in #HER2 mutant NSCLC from the SOHO-01 study at the #WCLC24 Presidential Plenary. Here: results from cohort D with prior therapy but no prior HER2 directed therapy

Dr. <a href="/LeXiuning/">Xiuning Le MD PhD</a> presents data on BAY 2927088 in #HER2 mutant NSCLC from the SOHO-01 study at the #WCLC24 Presidential Plenary. Here: results from cohort D with prior therapy but no prior HER2 directed therapy
Nagashree Seetharamu (@nagashreeseeth1) 's Twitter Profile Photo

Presidential symposium alert IASLC #WCLC2024- taking on the challenging NSCLC with HER2 mutations by its horns with promising targeted therapies

Presidential symposium alert <a href="/IASLC/">IASLC</a> #WCLC2024- taking on the challenging NSCLC with HER2 mutations by its horns with promising targeted therapies
Jarushka Naidoo (@drjnaidoo) 's Twitter Profile Photo

#WCLC24 Presidential II Ph I/II FURTHER trial of Firmonertinib for EGFR PACC mutation+ NSCLC: - 47pts - 2 dose levels 160mg QD, 240mg QD - ORR 63.6%, DCR 100%, 20.7% g3+ tox (240mg dose) - prolonged responses, 91% still on tx d.planchard Gustave Roussy Xiuning Le MD PhD IASLC #LCSM

#WCLC24 Presidential II

Ph I/II FURTHER trial of Firmonertinib for EGFR PACC mutation+ NSCLC:

- 47pts 
- 2 dose levels 160mg QD, 240mg QD
- ORR 63.6%, DCR 100%, 20.7% g3+ tox (240mg dose)
- prolonged responses, 91% still on tx

<a href="/dplanchard/">d.planchard</a> <a href="/GustaveRoussy/">Gustave Roussy</a> <a href="/LeXiuning/">Xiuning Le MD PhD</a> <a href="/IASLC/">IASLC</a> #LCSM
Chul Kim (@chulkimmd) 's Twitter Profile Photo

Extended follow-up of tarlatamab, DeLLphi-301. mDOR: 9.7 months mOS: 15.2 months (note no difference based on chemo-free interval) Cytokine release syndrome (CRS) mostly during cycle 1 Tarlatamab is an important tool for treatment of ES-SCLC #WCLC24

Extended follow-up of tarlatamab, DeLLphi-301. 

mDOR: 9.7 months
mOS: 15.2 months (note no difference based on chemo-free interval)

Cytokine release syndrome (CRS) mostly during cycle 1

Tarlatamab is an important tool for treatment of ES-SCLC

#WCLC24
Rami Manochakian MD, FASCO 🇺🇸🇸🇾CancerEducation (@rmanochakian) 's Twitter Profile Photo

🔥🚨1/2 OncoAlert Hot off the press. Just published Journal of Clinical Oncology in conjunction with presentation of overall survival data IASLC #WCLC2024. Results of #TROPION-Lung01 Study of #Datopotamab Deruxtecan Vs Docetaxel for Previously Treated Advanced #NSCLC. 👇🏼 ascopubs.org/doi/10.1200/JC…

🔥🚨1/2 <a href="/OncoAlert/">OncoAlert</a> Hot off the press.

Just published <a href="/JCO_ASCO/">Journal of Clinical Oncology</a> in conjunction with presentation of overall survival data <a href="/IASLC/">IASLC</a> #WCLC2024.

Results of #TROPION-Lung01 Study of #Datopotamab Deruxtecan Vs
Docetaxel for Previously Treated Advanced #NSCLC.
👇🏼
ascopubs.org/doi/10.1200/JC…