!! Our group's first publication is now available in the J. Am. Chem. Soc.! We developed a scalable, iron-catalyzed cross-electrophile coupling and used it in a number of applications! We sincerely thank reviewers for strengthening our report. Please join me in congratulating

Along with Megan Greaves, seoungtae kim, and our friends at Bristol Myers Squibb, we developed a Cu-catalyzed C–O coupling protocol using our newly developed ligand family that features a new ligand, mild reaction conditions, and interesting mechanistic insights. onlinelibrary.wiley.com/doi/10.1002/an…

Didn’t know a Wittig reaction could be enantioselective? Check out the latest instalment of our work in chiral lithium isothiourea boronates! pubs.acs.org/doi/10.1021/ja…

Congratulations to Professor Steve Buchwald (Buchwald Group), who has been named the recipient of the prestigious MIT Departmental Advising Excellence Award in recognition of his dedication to supporting students and his exceptional skills in advising. chemistry.mit.edu/chemistry-news…

If you’re stumped about what to get the Nobel laureate in your life, anecdotal evidence suggests a customized guitar may be a good option: cen.acs.org/people/Superst…

Excited to share our work on Copper Catalysed Asymmetric Formal Hydroformylation. Thanks to Peng Liu Group for a fantastic collaboration! pubs.acs.org/doi/10.1021/ja…

Pat Holland and Z rocking’ out.

‼️ I am thrilled to share our newest preprint describing the use of iron for a metal catalyzed C(sp3)–halide coupling with soft thiol nucleophiles! We are inspired by advances in iron catalysis happening across the world! Read our preprint here: chemrxiv.org/engage/chemrxi…

Now published J. Am. Chem. Soc.: We developed improved conditions for Cu-catalyzed C–N coupling that exhibit substantially improved functional group tolerance and enhanced catalyst stability. pubs.acs.org/doi/10.1021/ja…

How do you get clever, quick? Some of our Fellows gave fast and fantastic crash courses in printing proteins, neurobiology lessons from the “brainless” and science as social practice. Honing communications skills as part of their Science Leadership Program at our Summit today!

Congratulations to Gabriel Lovinger and Marcus Sak Marcus Sak on their paper in nature! A HBD catalyst accelerates an SN2 pathway despite H-bonding to the nucleophile by preorganizing the ion pair into a reactive conformation, just like an enzyme would! nature.com/articles/s4158…

Excited to share our newest strategy to access carbenes from aldehydes - now via radicals! Young & Jake found this highly practical, efficient, & selective way to make triangles - that even works in the presence of air or water! J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Jacobsen Lab reunion at Stereochemistry GRC 2024!

I’m very excited to share (a bit belatedly) this mechanistic story, published last week in Science Magazine: science.org/doi/10.1126/sc…

How do you turn a deletion into an insertion? In our latest, Myojeong shows that the anomeric amide can N-delete *and* re-aminate a sulfinate intermediate, enabling an overall SO2 insertion. Another great collab with Christopher Kelly and J&J! doi.org/10.26434/chemr…

Catalytic asymmetric dearomatization is a powerful tool to convert flat aromatic compounds into 3D scaffolds. However, catalytic asymmetric dearomatization via a radical mechanism is difficult. We provide a new biocatalytic solution: nature.com/articles/s4155…

Call for Papers for Joint Special Issues in Tetrahedron Letters and Tetrahedron in honor of Prof. Eric Jacobsen and Prof. Song Lin. Song Lin Jacobsen Lab For more information Check out: sciencedirect.com/journal/tetrah…

Super charged up to share that our latest electrifying work in collaboration with Julien Vantourout is out now in J Org Chem/Org Lett! Read about how the team developed an electrochemical synthesis of diazenes through anodic oxidation of sulfamides using SuFEx chemistry!⚡️🧪tinyurl.com/3428pvy8

And the 2025 Roger Adams Award goes to.....Dr. Eric Jacobsen, the Sheldon Emory Professor of Organic Chemistry at Harvard University! The award address will be given at NOS 2025 at RPI in Troy, NY and is sponsored by Organic Reactions and Organic Syntheses zurl.co/Q2vU