Just shy of 800 sequences contributed to COVID-19 Genomics UK (COG-UK) Consortium by our team since this all began. Thanks to all involved from UoN Life Sciences and Nottingham University Hospitals

🧬 The total number of #COVID19 sequences now released is 16,380. The sequences and analysis are freely available to view 👉 cogconsortium.uk/data

Fantastic to be a part of this innovative distributed network.

Massive achievement for @TeamNUH Microbiology lab, one of the first labs in the UK to obtain UKAS accreditation for SARS-CoV-2 PCR. A true testament to the hard work & dedication of the micro team, maintaining <24-hr TAT & high quality, end to end service for our patients.

About to start out 100th Oxford Nanopore run for covid samples with the team from Deep Seq . A sad milestone but amazing work by our local team including many from @TeamNUH and Patrick McClure all in support of the work of COVID-19 Genomics UK (COG-UK) Consortium .

Announcing the Visium Spatial Gene Expression for FFPE Scientific Challenge! Share how you’d use Visium Spatial to unlock the full story of your FFPE tissue samples to win an experiment performed by us. Enter by 12/23. Learn more: bit.ly/2IIPjlk #spatial

Great to see this paper out - loads of hard work from alex and many others to get this completed - adaptive sampling on Oxford Nanopore sequencers targeting hundreds of genes to depths in excess of 40x on a single flowcell. nature.com/articles/s4158…

Many application spin out of this on the fly selective sequencing. Tunable custom target panels to genome gap filling..... things get very interesting from here.

So - our ReadFish paper came out on Monday nature.com/articles/s4158… using GPU - but what if you only have a laptop? Here's an update from alex to our tools that enable ReadFish on Mac, Linux or Windows with no additional GPU or compute. looselab.github.io/2020/12/02/rea… for details.

One for #nanoporeconf

Well Oxford Nanopore - always seems to happen this time of year... bit of a bug in readfish but sure we will sort it out soon....

I still remember the first time I saw data from @scalene showing ultra long reads (N50>=100kb) were possible. Since then we and others (especially John Tyson) have worked to get longer reads. This weekend we tested the Circulomics Oxford Nanopore ultra long kits. Wow! 19.49 Gb N50 143kb

Earlier this week we put out a couple of preprints (doi.org/10.1101/2021.0… doi.org/10.1101/2021.0…) describing minoTour github.com/LooseLab/minot…, an Oxford Nanopore tool we have been developing for several years. A bit of a 🧵

We've put out a short preprint today showing some updates in Readfish for Oxford Nanopore adaptive sampling. biorxiv.org/content/10.110… alex is giving a talk shortly at the #nanoporeconf about this - but a short thread here.

Happy Christmas all!

This gif is from one sample of three run on a single Oxford Nanopore promethION flow cell. Frankly I'm super impressed at the performance though there is headroom for more improvements. We ran the same libraries as on gridION and have updated our preprint here. biorxiv.org/content/10.110…

Rapid #genome-wide copy number profiling using adaptive sampling on Oxford Nanopore by Matt Loose and the amazing team Deep Seq Real potential for clinical application.

We have an opportunity for someone to join our fabulous bioinformatics team - nottingham.ac.uk/jobs/currentva… - you will get to work with Oxford Nanopore Illumina @bionanogenomics 10x Genomics and more! Please retweet and dm for info!

Just a few flowcells to return to Oxford Nanopore