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#ISC25 Debate Intensive BP control <140 after ICH - NO says Dr Ortega from Cerebrovascular & Neurointerventional Lab 📈 Physiology: Pts unique autoregulation & risk perihematoma ischemia/AKI 🪝J-curve: harm if BP reduction too large 🧑‍🦯Meta-analyses = no mRS impact 🧑‍🤝‍🧑no one-size-fits-all approach!

#ISC25 Sung-Min Cho teaches points on LVAD-related stroke I never knew 📊Acute brain injury(stroke) is COMMON in LVAD pts (esp bleeds). Often can get CMBs incidentally. 💻role for pMRI for AC decisions in stroke ⚠️Risk features: low pulse pressure, VV cannula size, ΔPACo2

If you haven’t heard why Oxford Renal Studies Grp believe innovations in conduct of trials r more important than developing surrogates & new analytic methods then this is your bedtime read 4 tonight!!! Not exhilarating, until you see the magic of examples. academic.oup.com/ndt/article/40…

🚨BREAKING: Our report on the first-ever pig kidney xenotransplant in a living human with ESRD is now published in NEJM! A major milestone in transplantation, paving the way for a new era of organ replacement Mass General Transplant Mass General Kidneys eGenesis more: nejm.org/doi/full/10.10…

SGLT2 inhibitor (SGLT2i) Cold 🥶 Map: Indications for SGLT2i in CKD/ Albuminuria/ Type 2 Diabetes (T2D)/ Heart Failure (HFrEF, HFmrEF, HFpEF) from Int Society of Nephrology KDIGO RPA-Nephrology ASPC #Nephpearls #Cardiorenal #ISNWCN 🇮🇳 #WCN25 🇮🇳 👉 theisn.org/initiatives/to…

Take-home messages from #ISC25: ❌thrombectomy has likely achieved a ceiling effect (3 negative MeVO trial) 💉no-reflow phenomenon is real (positive trials of IA-TNK/tPA post-TICI2b/3) 💊 anti-GLP1s are the new statins (super effective) 🩸the clock ticks faster in ICH (code-ICH)

🚨 When the Brain Demands Hyperosmolar Therapy… But the Kidneys Say, “Not So Fast!” 🚨 🧠 Brain: “Mannitol, 3% saline—I need it now!” ⚠️ Kidneys: “And WHO’S cleaning up this mess?” 💡 ICU Reality Check! A TBI patient on mannitol & hypertonic saline suddenly develops polyuria,

Seamus Heaney, My Father, and Me - The Atlantic theatlantic.com/magazine/archi…

1/ After residency at Mass General Hospital, I reported to Atlanta to meet my fellow CDC Epidemic Intelligence Service Officers. I have never felt so intimidated by my peers The best and the brightest, they were star clinicians, had served in disaster zones; MD/PhDs and MSF.

Status epilepticus after cardiac arrest usually implies a poor prognosis. That may not be the case if seizures spring up in delayed fashion (I.e. day 2+) when EEG shows a continuous background. #curingcoma neurology.org/doi/10.1212/WN…

#STROKE: This topical review by Dearbhla Kelly et al. discusses the mechanisms of inflammation in chronic kidney disease, dialysis and associated therapies, and its proposed impact on stroke pathogenesis and prognosis. Eoin Kelleher #AHAJournals ahajournals.org/doi/abs/10.116…

The findings of this study highlight the substantial and growing Cardiovascular-Kidney-Metabolic (CKM) syndrome -related burden, emphasizing the urgent need for comprehensive and targeted interventions. bit.ly/JASN0658 #ASNJASN #diabetes

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘 for the next GREEN-K Webinar: "ISN GREEN-K Webinar: Green Initiatives & Challenges in Kidney Care from High-Income Countries." 🗣️ Caroline Stigant, Mark Harber 👤 Winston Fung, Dearbhla Kelly 🗓️ March 24 🕑 2 pm CET 🔗 Free registration:

𝗧𝗢𝗗𝗔𝗬: GREEN-K Webinar: "ISN GREEN-K Webinar: Green Initiatives & Challenges in Kidney Care from High-Income Countries." 🗣️ Caroline Stigant, Mark Harber 👤 Winston Fung, Dearbhla Kelly 🗓️ March 24 🕑 2 pm CET 🔗 Free registration: lite.spr.ly/6001GM0U #GreenNephrology

ISN GREEN-K Webinar: Green Initiatives & Challenges in Kidney Care from High-Income Countries Dr Caroline Stigant Dr Mark Harber  Int Society of Nephrology ISN Education #GreenNephrology #ThisIsISN #ISNWebinar

In this Editorial we present the novelties of ICM! link.springer.com/article/10.100…

Thank goodness people are waking up to the fact that there is a crisis for clinical research in the UK Financial Times High on the list are the bureaucratic processes that have become such an obstacle to getting things done

Great weekend read on the use and value of biomarkers in drug development📈📉 Although focused on neurodegenrative disease, a lot to learn with applicability across chronic diseases🧠💊