Our latest paper on pioneer transcription factor p53 is out. In this paper, we reported the cryo-EM structures of p53 bound to the nucleosome, in which nucleosomal DNAs are partially released from the octameric histone core. academic.oup.com/pnasnexus/adva…

It is official! We are now ACS Pride! Check out the change in handle (ACS Pride Subdivision of ACS PROF) and give us a follow.

The UC Davis Chemistry Department is looking to hire a new inorganic tenure track Assistant Professor! For more information on this position use the following link. recruit.ucdavis.edu/JPF05148?utm_c…

Our work from the Bret Freudenthal describing how the DNA repair protein APE1 binds and processes AP sites in the nucleosome is now out in Nature Communications! @NIGMS KU Cancer Center nature.com/articles/s4146…

Extremely excited to kickstart my lab TU München with Emmy Noether support from DFG public | @[email protected]. I’m very grateful to J. Keith Joung, my friends in Boston, and to A. Moretti, K.L. Laugwitz & C. Kupatt in Munich. More details & website coming soon. #CRISPR 🫀

my favorite thing about getting my PhD at UCD was quite literally the friends i made along the way. Joe Perryman and i were in the same cohort. 6 yrs later, we were married by his PhD advisor Jesús M. Velázquez with 4 UCD grad students standing beside me. grad school isn’t all bad!

Excited to share our new preprint reporting an HPLC-MS based approach to quantify cisplatin DNA intrastrand crosslinks in cells. Fantastic effort by postdoc Arnie Groehler to develop a new tool to investigate the basis of resistance to cisplatin therapy biorxiv.org/content/10.110…

Happy to announce that we won Best Poster at the 1st annual QBI Bay Area Chemical Biology Symposium. So proud to represent Fangfang Shen , @lmkdassama, Liting, Lisha Ou , nano-girl 👩🏽‍🔬, and I's work on targeted delivery and degradation of "undruggable" proteins in SCD!

In our recent preprint, we tested the requirements for the ssDNA-binding protein RPA in different stages of eukaryotic DNA replication… biorxiv.org/content/10.110…

I earned a badge from Schrodinger! A huge thank you to the ACS COMP + @Schrodinger partnership for offering free registration for the online course: Introduction to Molecular Modeling in Drug Discovery! It was a fantastic learning experience! api.badgr.io/public/asserti…

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

Just in! First selfie from our 2022 #NobelPrize laureate in chemistry Carolyn Bertozzi. Congratulations!

Don’t miss out on your chance to present a poster in person at the 2022 Inorganic Chemistry Symposium! For more information on posters and to register go to: chemistry.ucdavis.edu/seminars-event…

Happy to announce that our research focused on understanding the interaction between DNA repair proteins Ku and LigD has been published in nucleic acids research! Thank you to Monica Warner for her contributions to the project and @structureSara for her amazing mentorship! 🤩

If you're interested in DNA polymerase mechanism, check out our latest perspective from Bret Freudenthal and Washington Lab published in Current Opinion/Research in Structural Biology. sciencedirect.com/science/articl… We highlight new insights into DNA polymerase mechanisms provided by time-lapse X-ray crystallography!

The thought inside my head vs when I say it aloud to my PI

Extremely proud of JJ: first Ph.D. exit seminar of the Heffern Lab. It is hard to say goodbye to the 1st generation of students, but it also reinforces the awesome job I have to raise scientists who will do more than I can alone. Congrats Justin O'Sullivan!! #asstproflife

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