time.com/5754155/global…

“If at some point Earth becomes uninhabitable there’s no way to escape. We are linked to this planet.” Wishing a happy birthday to 2019 Physics Laureate Michel Mayor who delivered this important message during his Nobel Lecture. See more: bit.ly/2PGG2eR

Our latest review: The Control of Diastolic Calcium in the Heart. doi.org/10.1161/CIRCRE… British Heart Foundation National Institute for Health and Care Research

Circulation Research Review Alert! The Control of #Diastolic #Calcium in the #Heart: Basic Mechanisms and Functional Implications ow.ly/mHVm30qdE2m Authored by: David Eisner, JL Caldwell, AW Trafford & David C. Hutchings

Very proud of DaveHutchings and Cardiac Physiology team members for pulling together this British Heart Foundation funded translational paper out yesterday in Circ. Res. showing another cardioprotective effect of Viagra via prevention of cardiac arrhythmias. Division of Cardiovascular Sciences see bit.ly/3tdjnJc

Hutchings & colleagues discovered a novel #antiarrhythmic property of #PDE5 inhibitors via changes in #ECCoupling, leading to reduced SR Ca2+ content and suppression of Ca2+ waves. Learn more at ow.ly/e2oU30rSKXW DaveHutchings David Eisner GMadders

Congratulations to Isotta Castrini and all the co-authors for this important paper about Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive Kristina Haugaa Neal Lakdawala Thor Edvardsen JAHA ahajournals.org/doi/10.1161/JA…

Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling doi.org/10.14814/phy2.…

Thank you very much Journal of Physiology for the opportunity to comment on a thought-provoking paper from Andrew Trafford lab(doi.org/10.1113/JP2821…). Follow link below to read about the potential role of background Ca2+ influx on #AFib pathophysiology. David Eisner MBExC Jeremy Fauconnier

This #JournalClub article discusses the recent publication titled “Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart” by Hutchings et al. doi.org/10.1113/JP2821… Andrew Trafford Katharine Dibb

Research letter pre-print: the importance of potassium monitoring in CPVT. An inherited arrhythmia that is often misdiagnosed and mismanaged. Check it out if interested. Should be open access soon:authors.elsevier.com/a/1f2PA5VtUyOs… Division of Cardiovascular Sciences Cardiac Physiology @LIMR_ British Heart Foundation #cardiogenetics

A novel drug to prevent arrhythmia triggered by low potassium. This could potentially benefit lots of patients, especially those with heart failure or inherited arrhythmia. Division of Cardiovascular Sciences Cardiac Physiology @LIMR_ British Heart Foundation #cardiogenetics dx.doi.org/10.1111/bph.15…

Great to see this in all its glory in Journal of Physiology. Excellent team effort led by DaveHutchings from Cardiac Physiology and Division of Cardiovascular Sciences. Identification of TRPC6 channels in arrhythmia mechanisms. Thanks British Heart Foundation for funding. Andrew Trafford David Eisner Katharine Dibb

Fantastic to see our The University of Manchester paper on background Ca2+ influx in cardiac myocytes published in the Journal of Physiology. The size of this influx determines proarrhythmic Ca2+ waves, is increased in heart failure, and is carried via TRPC6 channels Thanks British Heart Foundation for funding

Are you a Cardiology or Obs & Gynae doctor? We would like to invite you to complete a very quick and easy survey about the long-term health effects of pre-eclampsia. An information leaflet will be available upon completion. Click the link to have a go! redcap.link/d7pgyaq4

Early morning lessons from David Eisner from Cardiac Physiology and Division of Cardiovascular Sciences on calcium buffering - the 99% you don’t see

Andrew Trafford presenting on the role of TRPC6 channels in #cardiac #arrhythmia - potential therapeutic target #IACS #IACS-ES meeting in Szeged #basicEP #electrophysiology #ionchannels

🚨We are looking for a Research Technician🚨 Excellent opportunity to work on parallel kidney and cardiovascular research projects at The University of Manchester with me, Samantha Borland and DaveHutchings Come join us 🥳 The University of Manchester Division of Cardiovascular Sciences jobs.manchester.ac.uk/displayjob.asp…

Pleased to announce a LifeArc funded post doc position in my group in Cardiac Physiology and Division of Cardiovascular Sciences. If you are interested in novel treatments for cardiac arrhythmias follow this link shorturl.at/dmxKT. Closing date is 17th March 2023. Please cascade to your networks

We are hiring! A BHF-funded three-year postdoc: Cellular arrhythmia mechanisms in lamin heart disease & preclinical testing of novel treatments. Patch clamp and Ca2+ imaging. To discuss: [email protected] Apply using link below: lnkd.in/ejxMF4ch