A new study shows that IRBP, a protein necessary for vision in vertebrates, was acquired from bacteria over 500 million years ago. Matt Daugherty Chinmay Kalluraya PNASNews article: ow.ly/B69l50NMksY Science Magazine digest: ow.ly/9JJI50NMksZ

Bacterial genetic origin in vertebrate eye evolution: Merchantoor recommends this Chinmay Kalluraya Matt Daugherty study in PNASNews that finds interphotoreceptor retinoid-binding protein was inherited by horizontal gene transfer into the vertebrate genome facultyopinions.com/article/742604…

Chinmay Kalluraya and Matthew Daugherty explain how vertebrates acquired a gene critical for vision from bacteria in the latest Science Sessions podcast: ow.ly/an8a50OurhW

Got a chance to share our story on a podcast with Matt Daugherty! Also my first time speaking on a podcast 🥳 Check it out here - open.spotify.com/episode/1NLk2i…

Innate immune #CARD8 mechanism for sensing #coronavirus & #picornavirus infection by detecting activity of #virus-encoded proteases; genetic variants in mammalian hosts affect which viruses can be sensed Brian Tsu Patrick S. Mitchell Matt Daugherty #PLOSBiology plos.io/43S8JZk

Biologists led by the Matt Daugherty have identified a previously unknown way that our immune system detects viruses. The immune protein CARD8 acts as a trip wire to detect a range of viruses, including the virus that causes COVID. today.ucsd.edu/story/research… PLOS Biology

Very proud of Lennice Castro for her first first-author manuscript! She wrote a fantastic review on the evolution and mechanisms of 'tripwire' sensing of viral infection by the CARD8 and NLRP1 inflammasomes. Many more great things to come from Lennice!

With #ASV2023 only a few days away, this seems like a good time to resurface here on Twitter. Come hear all about my research with ⁦Matt Daugherty⁩ on Saturday in the Innate Immune workshop. Can’t wait to connect with my fellow virologists for the first time since 2016!

Also, check out my episode of “Let’s Meet the Virologists” to learn a little about me and my career. Thanks to Larissa Thackray, Ph.D. 🇺🇦 🟦 for having me on!

So great to reunite with all of these wonderful friends and scientists to celebrate such a fantastic mentor. Congratulations Harmit S. Malik on all you've accomplished in the last 20 years!

New work from our Aligning Science Across Parkinson’s team: nature.com/articles/s4159…. Parkinson’s disease-linked LRRK2’s closest relative, LRRK1 is tightly regulated via different mechanisms than LRRK2. Great collaboration with Andres Leschziner, Matt Daugherty, and Knapp labs

Another great collaboration with Dengke Ma lab on the role of horizontal gene transfer (HGT) in providing novel functions to nematodes! Congrats to all, especially co-first authors Taruna Pandey and Chinmay Kalluraya !

I am delighted to share the latest preprint from our lab, which was work that was conceived and led by Jeannette Tenthorey during her postdoc and during the first few months of her independent lab at UCSF. biorxiv.org/content/10.110… TL;DR: Indels matter. A lot. 1/

Great work from Liz Fay and a team of undergrads she has assembled! So much interesting data in this paper (check out the paper and Liz’s summary). Definitely the first of many great papers from Liz on host diversity in immune responses!