Nearly all cells in our body have an autonomous circadian clock that controls ~40% of the genome. We show, at the single cell level, that the clock is mechanically controlled through YAP/TAZ. rupress.org/jcb/article-ab… IBEC

Our review on tissue fibrosis is out! We focused on studies employing single-cell transcriptomics. Several interesting patterns emerged, macrophages being front and center. nature.com/articles/s4159… Prakash Ramachandran UC San Francisco The University of Edinburgh #fibrosis #ipf #lung #ATS

CellAnn: A comprehensive, super-fast, and user-friendly single-cell annotation web server. #SingleCell #CellAnnotation #WebTool #Bioinformatics academic.oup.com/bioinformatics…

VCFshiny: An R/Shiny application for interactively analyzing and visualizing genetic variants #GeneticVariants #VCFvisualization #Rshiny #NGS #Bioinformatics Bioinformatics Advances academic.oup.com/bioinformatics…

JCB is pleased to present a special collection highlighting recent papers on the mechanical properties of cells and tissues, and the application & transmission of forces across scales relevant to cell biology. Gain new insights into #mechanobiology 👉 bit.ly/3sMxtF9

Excited to share #AlphaMissense our new AI system that can classify whether genetic mutations (missense variants) are benign or harmful - a critical step toward uncovering causes of many diseases, from cystic fibrosis to cancer. In Science Magazine today dpmd.ai/AlphaMissenseDH

Genetically modified silkworms successfully produce spider silk.; a natural fiber six times tougher than Kevlar. Read more in Matter_CP: cell.com/matter/fulltex… #SouthwestUniversty Qingyou Xia #DonghuaUniversity Qing Meng

CCPlotR: an R package for the visualization of cell–cell interactions by Sarah Ennis, Pilib Ó Broin, Eva Szegezdi doi.org/10.1093/bioadv… CCPlotR is available to download and install from GitHub (github.com/Sarah145/CCPlo…)🇮🇪

Do you want to model gene regulatory or co-expression networks based on large-scale heterogeneous data, such as data derived from different tissues or cancer types? Have a look at our new normalization method SNAIL 🐌, now out in Bioinformatics 👇: academic.oup.com/bioinformatics…

Excited to share our latest preprint: arxiv.org/abs/2310.04950 which shows how the feedback between mechanical strain and contractility can turn monolayer tissues into a mechanically-excitable medium, leading to the propagation of self-sustained waves.

We are pleased to announce that the #microphysio24 conference will be back at IES Cargese 23-27 Sept in 2024! We have a great list of speakers for this new edition. Please save the date and stay tuned for more information! Danijela Matic Vignjevic @Descroix16 Edouard Hannezo Caterina Tomba

Notch-mediated cellular interactions b/w vascular cells🤠 Arteriovenous identity via #EndothelialCell cell cycle+metabolism Organotypic vascular homeostasis Mural cell maturation Henar Cuervo Sebastian Mühleder IreneaBio Rui Benedito Curr Opin Cell Biol 2023 sciencedirect.com/science/articl…

“Self-Organization in Biology: Freiburg Spemann-Mangold Centennial Symposium” celebrates 100 years of scientific advances rooted in Mangold’s and Spemann’s discovery of the organizer, awarded the Nobel Prize in 1935. Outstanding line-up of speakers coorganised by International Society of Developmental Biology

Ramos, A. P., Szalapak, A., Ferme, L. C., & Modes, C. D. (2023). From cells to form: A roadmap to study shape emergence in vivo. Biophysical Journal, 122(18), 3587–3599. #EpithelialMechanicsReview cell.com/biophysj/fullt…

Active flows in biological systems swirl. A coupling between active flows, elongated deformations and defect dynamics helps preserve self-organised structures against disordered swirling. go.nature.com/3HEpq1i

Excited to finally share our work in Developmental Cell describing how Hippo pathway transcription regulators navigate the nuclear environment and interact with the genome to control gene expression in live tissues. 🧵1/8 authors.elsevier.com/c/1i~Wd5Sx5gxk…

Curious about what “nuclear envelope rupture” looks like, how that impacts heart functions, and why it may be important in heart disease? Check out our new paper in Cell Reports! cell.com/cell-reports/f…

New paper in Communications Biology! We show that Vimentin is a key regulator of cell mechanosensing. Depending on the stiffness of the microenvironment, disrupting Vimentin can decrease or increase actomyosin-contractility. nature.com/articles/s4200…

From MBoC Skokan et al. identify tissue-wide, constitutive macropinocytosis in the epithelium of Hydra and reveal a role for mechanical stretch in regulating this fluid engulfment phenomenon. doi.org/10.1091/mbc.E2…

Our most recent work on the “function and evolution” of #nuclear_speckles is now online at Cell Cell cell.com/cell/fulltext/… Read the thread 👇for the highlights of our findings.