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An informative Outlook by Xingui Liu and Alessio Ciulli illustrating the many processes that can be commandeered using chemically induced proximity (CIP) in research and drug discovery pubs.acs.org/doi/10.1021/ac…

Check out our latest paper describing non-covalent and non-peptidic Mpro inhibitors derived from DEL screening! nature.com/articles/s4200…

The rise of degrader drugs, a review by Mingxing Teng at BCMHouston and Nathanael S. Gray at Sarafan ChEM-H dlvr.it/Str3Yn

The 11th International Symposium on DELs really "DEL-ivered". Great event put on by Jörg Schuermann and Dario Nero at ETH. There is some highly innovative science being conducted in the DEL space that will undoubtedly lead to valuable probes and drugs in the future.

Let’s go! Amgen 🧪🔬🧬 #MyCompany

Just when you think JQ1 is out, it gets pulled back in… and with a longer half-life! Introducing JQ1-D. pubs.acs.org/doi/10.1021/ac…

nytimes.com/2024/01/12/bus…

Taking "induction of proximity" to a new level, Arena BioWorks, a Biomedical Research Institute that just launched in Boston, is bringing academic inquiry and biotech creation under one roof. prnewswire.com/news-releases/…

I wrote down my rules on how to Science. I hope you find it useful!

Today we celebrate Robert J. Gilliard, Jr., Novartis Associate Professor of Chemistry MIT Chemistry! He is a synthetic chemist whose research whose lab has developed synthetic methods to access molecules relevant to energy and environmental related problems. #BHM #BlackInChem #BlackandSTEM

From basic research to budding biotechs, under one roof with Stuart Schreiber bit.ly/3Tj5yaK Stuart Schreiber discusses his plans to tackle inefficiencies in the translation of biomedical research, through the newly launched for-profit institute Arena BioWorks

Is there an extended cut to this interview? I could listen to Stuart Schreiber all day long.

Novartis Associate Professor Robert Gilliard (Robert J. Gilliard, Jr.) embraces an expansive style of research, mixing different approaches and drawing from a variety of areas of expertise, including organic and inorganic chemistry. chemistry.mit.edu/chemistry-news…

I'm thrilled to announce that I will be chairing the 2026 Bioorganic Gordon Research Conference. Looking forward to assembling a fantastic group of scientists for this premier meeting. #grc #gordonconference #bioorganic

I am extremely grateful to be awarded a $5,000,000 Catalyst Grant from the Welch Foundation. This grant will be focused on further developing the science of DNA-Encoded Libraries (DELs) for generating small molecule ligands toward a broad spectrum of disease-related targets.

Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

My daughter Sophia is officially a freshman at Harvard. An amazing journey begins.

I'm inspired to be awarded a $4.2M grant from the Bill & Melinda Gates Foundation for developing chemical probes that will help bridge the gap to safe, effective, affordable and nonhormonal contraceptives for women. It is time to get to work!

Pleased to share our interesting story aimed at modulating MYC using PROTACS. MYC is cancer’s most notorious transcription factor, and our work demonstrates how elusive it can be. This paper also highlights how bifunctional PROTACS can promote some truly unanticipated outcomes.

welch1.org/news-reports/n…