On Tuesday, June 4, Mount Sinai hosted the Institute for Medical Education’s Excellence in Teaching Award Ceremony. We are proud to announce that two of our PhD students, Pushkala Jayaraman and Richard Quintana-Feliciano, were honored at the ceremony. Congratulations!

Authors Jithesh Kottur and Radhika Malik from Pharmacological Sciences report strucutres of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis nature.com/articles/s4146…

Happy to share Jithesh Kottur Radhika Malik paper from the Aneel Aggarwal lab published in Nature Communications. They report structures of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis. nature.com/articles/s4146…

Authors Jithesh Kottur and Radhika Malik from Pharmacological Sciences report strucutres of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis. nature.com/articles/s4146…

Excited to share our new study in collaboration with Gaurav Pandey where we explore the conformational space of protein kinases using AI-generated structures. Led by Noah Herrington with contribution from David Stein and Yan Chak (Richard) Li #alphafold #kinase dx.plos.org/10.1371/journa…

Join our Virtual Symposium in Big #DataScience on 8/8 @ 10 AM ET where the Ma'ayan Lab trainees in the 2024 Summer Undergraduate Research Training Program in Biomedical Big #DataScience will present their research projects. Register: mountsinai.zoom.us/webinar/regist…

From AviMaayan, Pei Wang, and colleagues: Multiomics2Targets identifies targets from cancer cohorts profiled with transcriptomics, proteomics, and phosphoproteomics: Cell Reports Methods cell.com/cell-reports-m… Icahn School of Medicine at Mount Sinai

New in JPET (ASPET): We show endogenous and small molecules like CBD act as chaperones modulating levels of Cannabinoid, Delta Opioid receptors and their interacting complexes with therapeutic implications for pathologies involving these receptors tinyurl.com/mv7duj6w

Excited to share our first cryo-EM paper, which was just published in Nucleic Acids Research: academic.oup.com/nar/advance-ar… We investigate a new family of RNases with crystal and cryo-EM structures. Congrats Ruoxi!

We are pleased to share a collaboration of the Aggarwal, Fang, Filizolalab, and Shapiro Labs publication in Nature Communications! nature.com/articles/s4146…

We are proud to share new exciting findings from the Yi Shi@Proteomics & Garcia-Sastre Lab. They have developed a novel antibody platform called AMETA. This platform harnesses multi-epitope targeting and avidity to combat viral mutational escape effectively. mountsinai.org/about/newsroom…

FRESH OFF THE PRESS Filizolalab : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10.10…

New lab picture: Filizolalab on the relentless quest for breakthrough science to build a brighter future. Bring it on!

Genes in cells are a bit like words, and gene sets are like sentences b/c genes are reused in different contexts; To learn the language of the cell, Ma'ayan Lab developed: A #GeneSet #FoundationModel Pre-Trained on a Massive Collection of Diverse Gene Sets biorxiv.org/content/10.110…

Amazing work by Dr. Rechkoblit et al. from the Aggarwal and Gang Fang Labs on CBASS Cap5 endonuclease showing bacterial self-destruction by digesting its own DNA! Congratulations! 👏 Happy to be part of this study. urldefense.proofpoint.com/v2/url?u=https…

Drs. Rechkoblit, Aggarwal & coauthors Pharmacological Sciences & Gang Fang unveil the structure of bacterial CBASS effector Cap5 degrading DNA, triggering bacterial self-destruction. External activation of Cap5 offers potential antibiotic strategy. Nature Communications bit.ly/40473611

Excited to see our new AI Small Molecule Drug Discovery Center Icahn School of Medicine at Mount Sinai featured in GEN! 🧬🧠 Read more: genengnews.com/topics/artific… Thank you Fay Lin, PhD and Genetic Engineering & Biotechnology News #AI #DrugDiscovery #Genetics

Join us on Thur. July 24 @ 2 PM ET for a virtual seminar about ChEA-KG, a newly developed Ma'ayan Lab web-based app that enables users to analyze their gene sets in context of a human gene regulatory network (1559 transcription factors). Please register at maayanlab.cloud/turl/35e9d6a0

Thrilled to co-host, alongside colleagues Drs. David Thomas and Michael Leitman, the inaugural symposium "AI in (Bio)Medical Education: Innovation in Teaching and Learning". Looking forward to a stimulating afternoon with Grad School at Icahn Mount Sinai and Icahn School of Medicine at Mount Sinai teaching faculty.