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So SO excited to share that our latest work—most of my PhD(!)—is now published in Science Magazine ! 🎉🐶 Our study on #Labradors reveals key #genetics behind #obesity, with insights for both dogs & humans. Huge thanks to our collaborators & the amazing dogs + owners! 🦮

Happy International Women’s Day! 🌎😄🧠💪 - from Lady GABA

Happy International Women's Day! Thank you for your hard work, courage, and strength. 💪 Together, we celebrate your achievement every day! #internationalwomensday

Hmm 😀

How a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia🟡, brain immune cells, accumulating where tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte🟣, pTau🔵

Our new preprint is out＠bioRxiv: biorxiv.org/content/10.110… Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

A heart muscle cell (cardiac myocyte) photographed through a microscope. Actin filaments are shown. #CellBiology

🚀Ever wondered if there's a universal rule of spindle scaling across eukaryotes? Turns out, there is! Our study reveals an evolutionarily conserved principle driven by a surprising factor: chromosome crowding. 🧵👇short-link.me/VOGP

If you are supervising an international student who is trying to write in their non-native language - tell them how awesome they are. They often feel incompetent, frustrated and even stupid. In reality they're really smart - just doing something very complicated. Tell them.

Today marks the beginning of OpenRxiv, which replaces bioRxiv and medRxiv, the world's largest preprint platform for life and medical science openrxiv

Girl with Bacteria

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…

Announcing Neo-1: the world’s most advanced atomistic foundation model, unifying structure prediction and all-atom de novo generation for the first time - to decode and design the structure of life 🧵(1/10)

A cell photographed through a microscope. The powerhouses of the cell, mitochondria (green), the Trans-Golgi Network (TGN) (red), and actin filament cytoskeleton (purple) are shown. #CellBiology

The ggalign package in R brings flexibility to your visualizations by helping align multiple plots and incorporate complex hierarchical data structures, like dendrograms, alongside your primary charts. This extension of ggplot2 makes it easier to organize heatmaps with clustering

Our new paper is out Science Advances👇 science.org/doi/10.1126/sc… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍Katsuhiko Minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2

Our work on HIV-1 matrix, led by James Stacey and Dominik Hrebik Dominik Hrebik, is in this week's nature. Extended explanatory video from Margot Riggi. nature.com/articles/s4158…

It's like ChatGPT, but for proteins 😍 See RFdiffusion in action. Instead of writing essays, this AI tool builds new protein structures from scratch, or based on your prompts (like a desired shape or motif). It's powered by a deep learning technique called diffusion models,

If you want to check if a human gene has copy-number changes or lands in a complex region, try pangene.bioinweb.org. Recently updated with more and better assemblies.