Happy to share our latest review which was done in collaboration with Prof Mark Herman on Chrebp roles in the liver and the pancreas. jbc.org/article/S0021-…

Nrf2 Regulates β-cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation diabetesjournals.org/diabetes/artic… Proud of Sharon Alterzon's Sharon Baumel-Alterzon and team's work here. Nrf2 necessary for adaptive b-cell expansion - and stimulation of Nrf2 sufficient to expand b-cell mass!

1/9. There has been a ton of discussion on academic Twitter about reasons to leave academia. This thread is for young scientists who want to stay in academia. Let me first comment on the things I agree with from the “time to leave” tweets:

Dear islet scientists, check our new manuscript in BioRxiv. Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profiles biorxiv.org/content/10.110…. Comments are welcome

“The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice” biorxiv.org/content/10.110… Nice work by Mark Herman's Lab!

Very happy to share our work was published today in Nature Communications. Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. nature.com/articles/s4146….

ChREBPβ, whether adaptive or maladaptive, is an important determinant of β-cell fate and a potential target for the preservation of β-cell mass in #diabetes #islets #T1D #T2D Nature Communications nature.com/articles/s4146…

Happy to share our newest paper is out! Molecular Metabolism T3 and Glucose Increase Expression of Phosphoenolpyruvate Carboxykinase (PCK1) Leading to Increased ß-Cell Proliferation sciencedirect.com/science/articl…

During neonatal ages, there is a big burst of beta-cell proliferation that contributes to beta-mass in adulthood. Both oxidative stress and NRF2 seem to have an important role in this process. Come and hear all about it at the coming #ADA2023.