An extraordinary case of rare En(a-) RBC phenotype due to lack of glycophorin A. Strong anti-Ena antibodies, HTR after 24 hours after transfusion. No En(a-) donors in USA, compatible blood found in Qatar. tinyurl.com/4h8jv9cr

#blood_groups
#glycophorins

Hervertov, Slovakia. Wooden church of St. Francis of Assisi built by the end of the 15th century.

Canon R, 24-105 mm.

Successful management of maternal anti-PP1Pk alloimmunization in pregnancy with therapeutic plasma exchange and intravenous immunoglobulin

onlinelibrary.wiley.com/doi/10.1002/jc…

#blood_groups

Sphingolipid biosynthesis is essential for metabolic rewiring during TH17 cell differentiation buff.ly/4beRsO9 (Science Advances)

A prion-like domain is required for phase separation and chloroplast RNA processing during cold acclimation in Arabidopsis

academic.oup.com/plcell/advance…

Excellent review by Pamela Stanley Nature Reviews Genetics about genetics of glycosylation. Must-read!

tinyurl.com/2w2nfx4y

#glycotime

O-GlcNAcylation and immune cell signaling: a review of known and a preview of unknown. Immune system development, role in neutrophil/myeloid/NK/mast/TCR/BCR signalling. O-GlcNAcylation and other posttranslational modifications. Journal of Biological Chemistry tinyurl.com/2xy64r32

#glycotime

Interesting review about glycosylation of fibroblast growth factors (FGFs) and their receptors (FGFRs): N- and O-glycosylation, secretion/stability/function, intracellular trafficking, regulation of FGFRs interaction with FGFs and co-receptors. tinyurl.com/4jvmyawa

#glycotime

Human Milk Oligosaccharides (HMO) could be important in infant #nutrition #development and #immunity . Research on the diverse pool of HMO's requires #synthesis of individual members. Alexei Demchenko, PhD (he/him) and colleagues report synthesis of two common hexasaccharides doi.org/10.1002/chem.2…

Comprehensive lipidomic analysis of the genus Cutibacterium (eg C. acnes, C. granulosum): 128 lipids identified, incl. markers as phosphatidylcholine PC 30:0, sphingomyelins 33:1, 35:1) and phosphatidylglycerol with an alkyl ether substituent PG O-32:0.

tinyurl.com/tjfkxz2z

🔥🔥🔥my 💯 paper is out, congrats 🎈🎉🍾 David Meyer for this amazing story. Aging clocks tick by the noise: we can build aging clocks 🕰️ on accumulating stochastic variation! CECAD Cologne Universität zu Köln Cologne Graduate School of Ageing Research Uniklinik Köln follow 🧵retweet & read now open access: nature.com/articles/s4358…

Some impressions of today’s excellent online Beilstein-Institut [email protected] seminar given by Ben Schumann: Bump/hole approach for examining GalNAc and Xyl transferases. #glycotime

Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4 buff.ly/3UITD6K (Journal of Lipid Research)

Iñaki Ruiz-Trillo searching for the unknown!

first JACS in our small institute
pubs.acs.org/doi/10.1021/ja…

Rhnull phenotype in an Indian patient due to a novel c.1138 + 2 t > a mutation in the RHAG gene
onlinelibrary.wiley.com/doi/10.1111/tm…

Excited to share our latest #glycotime work Nature Communications highlighting the mechanistic differences between a Toxoplasma Gondii GalNAc-T and its human relatives. Congratulations to Dr. Pranav Kumar in our lab NIDCR @NIH for his incredible work! rdcu.be/dG7do

Glad to see this preliminary analysis of #influenza sialic acid receptors in the bovine mammary glad. But I worry people are WAY overinterpreting a narrow methodology, re: mixing vessel. We have a lot more to learn. #H5N1

biorxiv.org/content/10.110…

Two glycosyltransferases of Yersinia spp. (YeGT and YkGT) modify Rho family proteins by attachment of GlcNAc at Tyr residues. Crystal structure, specificity determined and effector functions determined. Journal of Biological Chemistry
tinyurl.com/mtxkkcan

#glycotime

Bardejov, Slovakia. Town Hall and basilica of St. Giles.

Canon R, 17-40 mm.