Today we have received the Narcís #Monturiol medal from #conseller Joaquim Nadal Recerca i Universitats This wouldn’t have been possible without an amazing Team 🔝🔝 and the continued support of Universitat Autònoma de Barcelona Institut de Biotecnologia i de Biomedicina UAB @Biociencies_UAB Thanks ☺️

nature.com/articles/s4146… In where we show that dynein adaptors, like most things in life, are also regulated by phosphorylation. Featuring: BICD2 and PLK1. You heard that right: no NEKs this time (but, of course, just wait).

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family nature.com/articles/s4146…

I dont want to be part of a system that is so horrifically broken and serves to benefit the few 🧵5/5

New steps expanding #targetedproteindegradation (#TPD) to tackle neurodegenerative diseases. #synucleinopathies pubs.acs.org/doi/10.1021/ac…

If we have to have northern lights, let’s have northern lights.

The 26S proteasome is this fantastic machine that nature has created to achieve homeostatic control of intracellular protein content in a timely and perfectly regulated manner. Most of the strategies used in the #TPD field rely on that. #Proteindegradation

Spectacular tuning effect of Usp14 mediated by 3 allosteric checkpoints that make the 26S proteasome even more sophisticated. Thanks Y. Mao, D. Finley and all contributors. Retain in memory. nature.com/articles/s4158…

Let's be clear: this is beauty. (historical picture of Ordesa valley, #MontePerdido presiding, at the heart of Pirineo de Huesca)

Can allostery be decoded? the complexity of allosteric regulation, essential to understand cell biology and pharmacology, approached from different standpoints in two outstanding papers: elifesciences.org/articles/83477 nature.com/articles/s4158…

Fascinating parallel architecture and functioning of Npl4-Ufd1-CDC48 and 19S Proteasome complexes. The same evolutionary solution put together twice in the same pathway: Ubiquitin recognition, MPN domains and ATPase engine. #TPD pubmed.ncbi.nlm.nih.gov/36736315/ pubmed.ncbi.nlm.nih.gov/37311459/

I think this paper by Gygi Lab is just about the coolest thing I've seen all week. Hats off to them!🥳 nature.com/articles/s4158…

Certain MEK inhibitors induce a complex between #MEK & difficult-to-degrade #cRAF. This allows bystander degradation of recalcitrant cRAF w/ #PROTACs targeting MEK. Excellent study by the Duncan & Jin labs Fox Chase Cancer Center Icahn School of Medicine at Mount Sinai bioRxiv biorxiv.org/content/10.110…

Sala plena en el retorn de Secció Ciències i Tecnologia - Ateneu Barcelonès! 📊 De què parlem quan parlem de dades? Realitats, Mites i Futurs Amb Pau Garcia, de Domestic Data Streamers i Mercè Crosas, del BSC-CNS

July 6th, 12pm EST Bernat Crosas Bernat Crosas (IBMB) 26S proteasome PROTACs. Matthias Muhar (ETH Zürich) C-terminal chemical degron.

Join us next week for #DegradoZoom on July 6th, 12pm EST: Bernat Crosas Bernat Crosas IBMB: Development of proteolytic chimeras based on direct 26S proteasome targeting Muhar Matthias Matthias Muhar ETH Zürich: A chemical degron marks C-terminally modified proteins for degradation

Our paper describing the 3Å #cryoEM structure and chain-elongating function of UBR5, one of the largest HECT E3 ligases, is now out! at embopress.org/doi/full/10.15…

If you're interested in degrading the "undruggable", you should pay close attention to what aptamers can do for you. #TPD pubmed.ncbi.nlm.nih.gov/37380531/

Extraordinary mechanistic dissection of proteasome activities and definition of roles of ubiquitin beyond substrate recruitment. Always Andreas Martin Lab ! pubmed.ncbi.nlm.nih.gov/36563145/

Well done, sister!