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Patho-DBiT, for the first time, maps spatial distribution of microRNAs in clinically archived FFPE tissues and reveals their regulatory roles in tumorigenesis! #NobelPrize2024

The best timing for genomics profiling in #PDAC is on the diagnostic biopsy. But now we know that it can even be done on whatever comes out when the needle is washed! RNA and DNA predictive biomarker from rinsing EUS-FNA, a multicentric study: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

New online! Digital twins are integral to personalizing medicine and improving public health go.nature.com/3zSnRwv

REVIEW npj Journals Systems immunology approaches to study T cells in health and disease nature.com/articles/s4154…

Prediction of brain metastasis development with DNA methylation signatures nature.com/articles/s4159…

Immune system one pager

NEW content online! Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells go.nature.com/3YkwcCs

Here comes our new Cancer Cell review on #hallmarks of #cancer #immune escape. Introducing the new framework of the #3Cs! kudos to Claudia Galassi, PhD and Ilio Vitale for doing the heavy lifting. Thanks to Timothy Chan for input!!

Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy | Science science.org/doi/10.1126/sc…

Delighted to share our paper on the NeoDisc pipeline, developed by the super-talented Florian Huber. NeoDisc is an ‘end-to-end’ clinical antigen discovery pipeline, integrating genomics, transcriptomics and immunopeptidomics nature.com/articles/s4158… HUPO-HIPP

A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy go.nature.com/4eEVVvo

Online Now: The hallmarks of cancer immune evasion dlvr.it/TFFy1H

Biological Age Vs. Chronological age is often discussed in academic and public discourse. This article in Nature Medicine is a good read to understand the use and misuse of various "Aging clocks" nature.com/articles/s4159…

Time to rethink platinum choices in the era of immunotherapy in lung cancer - Annals of Oncology annalsofoncology.org/article/S0923-…

The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution biorxiv.org/cgi/content/sh… #biorxiv_cancer

🟠Trials in advanced pancreatic cancer👇 ❌Failure and ✅Success ESMO - Eur. Oncology OncoAlert #cancer #oncology #pancreatic #MedX

Molecular matching correlates with increased survival in unicorns. Especially important since often ultra-rare cancers don’t have good standard therapies. 🎯🎯👉🫵 iScience 2024 sciencedirect.com/science/articl…

Check out this excellent review in Nature Reviews Cancer from my former lab on how cancer preconditions distant tissues, setting the stage for metastatic colonisation. Congrats Nick Rabas Rute Ferreira Stefania Di Blasio ilaria Malanchi! 🎉 nature.com/articles/s4156…

A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial dlvr.it/TFL95P

We discuss here the dual resistance to mFOLFIRINOX and gemcitabine, the role of transcriptomic signatures in reducing toxicity and guiding treatment decisions for operable and metastatic patients reinforcing their potential for personalized treatment.annalsofoncology.org/article/S0923-…