Exposure to the smell and taste of milk with tube feeds may have little to no effect on time to reach full sucking feeds and full enteral feeds. No clear difference between exposure and no exposure to the smell or taste of milk on safety outcomes.
cochranelibrary.com/cdsr/doi/10.10…

Despite the increasing use of dexmedetomidine, there is insufficient evidence supporting its routine use for analgesia and sedation in newborn infants on mechanical ventilation. Furthermore, there are no data available on its long‐term effects. Link ⤵️
cochranelibrary.com/cdsr/doi/10.10…

To evaluate the effects of nasal high‐frequency ventilation compared to invasive ventilation via an ET tube or other non‐invasive ventilation methods in preterm and term infants with or at risk of respiratory distress.
This review included 33 RCTs ⤵️
cochranelibrary.com/cdsr/doi/10.10…

Matteo Bruschettini Brett J. Manley 🤷🏼‍♂️ It is important to still publish reviews which include only one study (or no studies) to show a lack of evidence in the field. The review authors can highlight the need to conduct further trials to provide evidence of the benefits/harms of the treatment.

Late systemic administration of dexam. is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD.
Endotracheal instillation of budesonide with surfactant as a carrier is a promising intervention.
doi.org/10.1002/146518…

Bronchodilators are widely used in North American neonatal units for #BPD management. However, their widespread use is in the absence of evidence and despite the intervention potentially having adverse effects. Read the update of this Cochrane review:
cochranelibrary.com/cdsr/doi/10.10…

Listen to the latest Cochrane podcast:
cochrane.org/podcasts/10.10…
Title of the review: Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta‐analysis

Podcast now available: cochrane.org/podcasts/10.10…

The Cochrane Library Cochrane ChildHealth Cochrane

This update included 19 new studies (in total 44 studies, 5051 participants).
Early developmental intervention:
- may improve cognitive outcomes in infancy
- improves cognitive outcomes at preschool age
- may not improve cognitive outcomes at school age

cochranelibrary.com/cdsr/doi/10.10…

This review included 9 RCTs (383 preterm infants).
There may be little to no difference between early and late administration of amino acids in growth during the first month after birth and neurodevelopmental outcome.

Link: cochranelibrary.com/cdsr/doi/10.10…

This review update includes 8 RCTs (510 newborns).

Laryngeal mask surfactant (S‐LMA) was compared with:
- surfactant via ETT with InSurE (5 RCTs)
- surfactant via ETT and later extubation (1 RCT)
- no surfactant administration (2 RCTs)

Link: cochranelibrary.com/cdsr/doi/10.10…

Medicine‐free management of #neonate #pain during endotracheal suctioning 👶
📚 🔍 This Cochrane Neonatal @ #SystematicReview looked at the evidence from 8 studies w 386 #infants assessing 6 different ways of reducing pain.
buff.ly/4b00a3d

This review:
- aimed to evaluate the efficacy and safety of administering probiotics after gastrointestinal surgery for the postoperative management of neonates born from 35 weeks of gestation.
- identified one RCT (recruiting 61 neonates)
- full text: cochranelibrary.com/cdsr/doi/10.10…

New Cochrane Review - facilitated tucking / four‐handed care / gentle human touch:
- probably reduces PIPP score
- slightly increases self‐regulatory and approach behaviours during endotracheal suctioning

cochranelibrary.com/cdsr/doi/10.10…

Listen to the latest Cochrane podcast:
cochrane.org/podcasts/10.10…

Topic: different positions for spinal taps in infants.
Most studies compared lateral decubitus to sitting position.

Vermont Oxford Cochrane Cochrane ChildHealth The Cochrane Library Olga Romantsik Matteo Bruschettini

Automated oxygen delivery compared to routine manual oxygen delivery probably increases time in desired SpO2 ranges in preterm infants on respiratory support. However, it is unclear whether this translates into important clinical benefits.
cochranelibrary.com/cdsr/doi/10.10…

Oral dextrose gel reduces the risk of hypoglycemia (HG) and probably reduces the risk of receipt of treatment for HG, but probably makes little or no difference to the risk of receipt of intravenous treatment for HG.
(Evidence from 2548 infants)

Link: cochranelibrary.com/cdsr/doi/10.10…

This Cochrane Review aimed to evaluate the benefits and harms of stem cell‐based interventions for the treatment of stroke in newborn infants compared to control (placebo or no treatment) or stem‐cell based interventions of a different type or source.
cochranelibrary.com/cdsr/doi/10.10…

Evidence from 11 RCTs (1185 infants) in high‐income countries:
- unsure if feeding healthy infants high‐protein formula has an effect on undernutrition, overweight, or obesity
- there may be little or no difference in the risk of adverse effects.
Link: cochranelibrary.com/cdsr/doi/10.10…

This review included 18 RCTs on the use of any methylxanthine in preterm infants for: any indication (1 study); prevention (6 studies) or treatment of apnea (5 studies); and to prevent re‐intubation (6 studies)

Methylxanthine reduces chronic lung disease
cochranelibrary.com/cdsr/doi/10.10…