In zebrafish embryos, cytoplasmic streaming leads to the segregation of embryo from yolk granules. Credit to Heisenberg Lab. #ZebrafishZunday

Want to optimize or deoptimize gene expression in vertebrates? Check out our new tool: iCodon 😎 BazziniLab Stowers Institute @GSSIMR

Congrats to Marlies Rossmann on our recent paper in Science. We found that mitochondrial metabolism and coenzyme Q synthesis directed by the cell-specific transcription factor TIF1g is required for blood cell development. science.sciencemag.org/content/372/65…

Wondering how to uncover the RNA-binding proteins bound specifically to the viral RNAs? Check the new work from the Castello Lab #SARS_CoV_2 sciencedirect.com/science/articl…

Not an NGG available in that target that you must edit? What about just NGN? Yes? Then check the latest pre-print from Moreno-Mateos Lab for new Cas9 variants with minimal PAM sequence requirements biorxiv.org/content/10.110…

new Lai lab paper! are you curious about regulation of miRNA processing? check out new study on surprising strategy that mir-144, the partner of Dicer-ind mir-451, is made as a suboptimal hairpin and needs RBP help to reshape as a good Dicer substrate! 1/3 academic.oup.com/nar/advance-ar…

How do Dicer-1 and Loqs-PB make miRNA? We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loqs bend pre-miRNA to cleave the right targets: cell.com/molecular-cell… Fun collab. with ZamoreLabUMass and Traci Hall (NIEHS). Congrats,Karina Jouravleva and Dima!

We are looking for an #RNA wizard to unlock the mysteries of RNA regulation by RNA-binding proteins in viral and vertebrate systems. If you are the One, apply for a postdoc position in the Cifuentes Lab! cifulab.com ; rnasociety.org/postdoctoral-p…

More thoughts on the demise of disruptive science. Take Fred Sanger, 2x Nobel Prize winner. Sydney Brenner wrote about him in an obituary that multiple times in Fred's career, he went 10+ years without publishing as he was working on 'disruptive' science. science.org/doi/full/10.11…

Jenna Galloway Trista North and I are organizing a Boston Area ZebrAfish Researchers (BAZaR) meeting at Boston College on March 18! Please get the word out and let us know if you plan to come! sites.google.com/bc.edu/bazar

I am excited to present this work led by Frederick Rehfeld (not on Twitter). We performed genome-wide CRISPR screens to identify host factors required for programmed ribosomal frameshifting by SARS-CoV-2. 1/4 cell.com/cell-reports/f…

Re: the history of the DNA structure, see this blistering 1967 letter from Crick to Watson objecting to the draft of Watson’s book on their work. “...it shows such a naive and egotistical view of the subject as to be scarcely credible.” profiles.nlm.nih.gov/spotlight/sc/c…

Dengue virus preferentially uses human and mosquito non-optimal codons

Wondering how microRNAs can have mighty impacts on the transcriptome? Here (rdcu.be/dHdub) we show how miR-144 effects expand beyond its direct targets by targeting a chromatin regulator during hematopoiesis. Congratulations, team!

Dr. dmitry_kretov led this research showing that miR-144 single-handedly regulates multiple chromatin factors to force #erythrocyte progenitors into the differentiation pathway. Congratulations to everyone involved! 🎊 Cifuentes Lab George J. Murphy go.nature.com/3UzT9yM

Our new preprint is Biorxiv! CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of the maternal-to-zygotic transition in teleosts Centro Andaluz de Biología del Desarrollo. Another fantastic collaboration with BazziniLab Stowers Institute. biorxiv.org/content/10.110… A thread(1/10):

Davor Lessel briefing us on the progress on human Ago mutations. A lot has happened, but there’s still a lot to be done. We need both, brilliant minds and financial resources, to fully understand Ago syndromes and thereby help patients

Victor Ambros and Daniel Cifuentes have made clear the importance of research in model organisms, like C.elegans 🪱 or zebrafish 🐟, to understand human disease 👏👏

Congratulations!! Well deserved and long due!