🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We investigated the tumor microenvironment (neutrophils and fibroblasts) in this study. As a transcription lab, we clearly needed some help. A big thank you to Cold Spring Harbor Laboratory collaborators in the Tuveson (esp Giulia Biffi) and Mikala Egeblad labs. elifesciences.org/articles/53381

We recently updated our lab website vakoclab.labsites.cshl.edu

Happy to see our paper functionally characterizing the TF ZBED2 as an interferon pathway regulator out in PNASNews implications for immune regulation and cell identity in PDAC Christopher Vakoc @diogomaiasilva @xlw1207 Yali Xu Cold Spring Harbor Laboratory pnas.org/content/early/…

Tim, it has been a privilege to work with you and to publish these three studies together. The squamous PDAC research will continue here, building upon your work.

Here is the Tim Somerville trilogy on squamous subtype PDAC. pnas.org/content/early/… elifesciences.org/articles/53381 sciencedirect.com/science/articl…

ZBED2 Funfact#1: It belongs to the BED family of zinc finger proteins that evolved from a domesticated hAT DNA transposon. ZBED2 is only 218 aa, and lacks the catalytic domain, but retains its BED-subtype zinc finger for DNA binding. journals.plos.org/plosone/articl…

ZBED2funfact#2: This gene evolved recently and there is no mouse ortholog. This might be why ZBED2 had not been studied before and poses challenges for studying its function in a model organism. journals.plos.org/plosone/articl…

ZBED2funfact3: The normal expression pattern of ZBED2 in skin and esophagus suggests a role in normal squamous lineages, which might be related to the biased expression of ZBED2 we see in adenosquamous pancreatic tumors. pnas.org/content/early/…

Proud to share our work on dissecting the epigenomic changes brought on by pregnancy in mammary epithelial cells and their effect on normal and malignant development! A big shout out to my amazing lab for all of their dedication. nature.com/articles/s4146…

We are excited to share the publication of our manuscript, “High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening,” in Nature Communications today! nature.com/articles/s4146…