Childers Lab
@childerslab
We apply biochemistry, synthetic biology, and chemical biology to study how phase separation organizes the bacterial cytoplasm and how bacteria make decisions.
ID: 1034155039458295808
https://childerslab.weebly.com/ 27-08-2018 19:05:49
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What determines polar mRNA localization in E. coli? Shanmugapriya Kannaiah, Orna Amster-Choder et al Faculty of Medicine - The Hebrew University find the polar transcriptome to depend on MinD inhibition of RnaseE recruitment embopress.org/doi/full/10.10…
🙏 to Annual Reviews for the opportunity to write this review w/ Cary Boyd-Shiwarski, MD/PhD on molecular #crowding for the physiologist. We cover emerging connections between crowding sensing & diverse functions, highlighting #IDRs and #condensates as key mediators. annualreviews.org/doi/full/10.11…
Thrilled to finally announce our work on the selectivity of disordered protein condensation in Nature Chemistry. Great collaboration with Jeetain Mittal Led by Rachel Welles and Kandarp Sojitra. rdcu.be/dxP4r. See related work by Brangwynne lab rdcu.be/dzddw
Thrilled to share our latest preprint about asymmetric division in E. coli! Work led by the amazing Yashna Thappeta & Silvia Cañas-Duarte. Fun collaboration with the Cegelski lab. biorxiv.org/content/10.110…
Our c-di-GMP sensor story is finally out in Nature Communications: rdcu.be/dHsEh. Including new data demonstrating cdGreen2 as a convenient tool to study DGC and PDE activity in vitro. Great collaboration with Simon van Vliet and Maier Lab!
Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Life Transitions by W. Seth Childers and co-workers Childers Lab #OpenAccess onlinelibrary.wiley.com/doi/10.1002/sy…
Just online Nature Communications cationic peptide nanotubes can bind weak hydride transfer agents to facilitate efficient reduction of esters in water! Grateful to Swarnajayanti Grant, SERB , CSIR & IISER Kolkata rdcu.be/dJbwI #systemschem #enzymemimics
Pick of the Week, out #OpenAccess in ChemSystemsChem by Childers Lab: Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Life Transitions ow.ly/kP6W50S9Vjo SystemsChem Talents: ow.ly/opyk50S9Vs3
So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12
Check out our latest paper in Nature Chemical Biology, where we developed our CAGE split intein platform to study signaling events using proteomic profiling. This enables insights into the differential molecular connections of fusion oncogenes. Congrats to Gihoon Lee! nature.com/articles/s4158…
🔬🦠 Read our latest review tinyurl.com/2y9ebsgl in PLOS Pathogens on bacterial condensates, their role in stress sensing and response, and potential for influencing host-pathogen interactions. Fun project with the Childers Lab. Congrats to Moeka Sasazawa and Dylan Tomares
Controlled Protein-Membrane Interactions Modulate Self-Organization of Min Protein Patterns (Katja Zieske and co-workers) Katja Zieske Max Planck Institute for the Science of Light #openaccess onlinelibrary.wiley.com/doi/10.1002/an…
Many thanks to American Physiological Society #TPhysMag for featuring us in this month's "Under the Microscope"... Was fun to do this interview! Univ of Pitt Center for Kidney Research physiology.org/publications/n…
