I cannot be part of any online community that actively promotes hate. Find me at ChemKritzer on Mastodon.

There are direct connections between online communities that promote hate and bomb threats, shootings, etc. Consider doing this small thing to make the world safer for all.

Congrats Sam! A well-deserved honor!!!

Excited to share, along with brilliant collaborators, Squire J. Booker & Ed O'Brien Penn State Chemistry, our paper in Nature Chemistry explaining the biophysical basis of how synonymous codon mutations can alter protein structure and function. Short 🧵1/9. nature.com/articles/s4155…

Kritzer Lab holiday party was full of laughter and light. I am so lucky to work with such an amazing group of scientists!!

The findings were astonishing. RFdiffusion, alongside better computational filtering methods, gives ~100x the success rate of previous methods!

1/
When I saw you on rounds that morning you were quiet. Your eyes looked in my direction but were otherwise vacant.

This was a change.

Me: 'You okay?'
You: 'Yup.'

There was coolness in the way you spoke. After that, you turned away from me and faced the wall.

Ooph.

From the perspective of a former study section chair, the suggested reviewing changes from NIH look great. They are open for comments.

“Update on Simplifying Review Criteria: A Request for Information” nexus.od.nih.gov/all/2022/12/08…

I am recruiting at least one, maybe two PhD students to join my lab at Tufts University School of Engineering in Fall 2023. We work on developing new polymeric materials for membranes, but also have collaborative projects on energy storage and biomaterials. We take pride in supporting our students, 1/

Woohoo! Big congrats to Jiaqi Shen, Lequn Geng and Xingyu Li for all their collaborative work leading to a brand new publication in Nature Methods! Our group teamed up with Prof Peng Li’s Lab 👏🏻!!! (@UMLifeSciences & UM SchoolofDentistry) nature.com/articles/s4159…

We just published our development of a photocaged orexin-B for spatiotemporally precise control of orexin signaling in ⁦CellChemicalBiology⁩ 🥳 Great collaboration with the lab of ⁦tommaso patriarchi⁩ ⁦Universität Zürich⁩ ⁦UZH Chemistry⁩ cell.com/cell-chemical-…

Crabtree and Gray labs introduce #TCIPs ! Demonstrating that chemical induced proximity between transcription factor #BCL6 and #BRD4 , activates downstream #BCL6 target gene expression and results in potent apoptosis. Go go marvels of #inducedproximity !
biorxiv.org/content/10.110…

I'm happy to share the preprint 'Mega-scale experimental analysis of protein folding stability in biology and protein design' This work is supervised by Gabriel Rocklin
Justas Dauparas and Sergey Ovchinnikov 🇺🇦 provided designs! 1/n
biorxiv.org/content/10.110…

Congrats to Shi and Zhen for their recent paper in PNAS 'Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo' pnas.org/doi/10.1073/pn…

Saying 'I might be wrong' is not a mark of ignorance. It reveals the absence of insecurity.

Arrogance is a shield for a fragile ego. Humility is a sign of self-assurance.

It takes confidence to admit uncertainty. The people who are the most sure are usually the most insecure.

Activate proteins w/ magnets. 🧲

An 'Electromagnetic Perceptive Gene' from ghost catfish changes shape in magnetic fields.

When fused to protein halves, makes 'magnetogenetic' proteins that join via magnetic induction (slow response).

First of its kind. biorxiv.org/content/10.110…

Here’s a general rule of thumb for assessing inclusivity. True inclusivity is flexible. It adapts to the individual. It allows for many ways of being and learning. 1/

Thrilled to share this story in JACS Au, w/lots of new data since the preprint! pubs.acs.org/doi/10.1021/ja…
2 takeaways: (1) analogs of PC lipids w/different choline structures adopt different organelle localizations & are useful for tracing inter-organelle lipid transport, & 1/2

Proline C-H Bonds as Loci for Proline Assembly via C-H/O Interactions (Zondlo) Zondlo Lab Univ. of Delaware onlinelibrary.wiley.com/doi/10.1002/cb…

First-generation college students need mentors who believe in us | Science | AAAS ⁦Science Magazine⁩ science.org/content/articl…