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IISER Bhopal Researchers Identify Mechanism of Breast Cancer Progression highereducationdigest.com/iiser-bhopal-r…

NDTV Education covers recent work from Dr. Sanjeev Shukla’s laboratory, which was published in journal Oncogenesis. Ministry of Education DBT/WT India Alliance Prof Siva Umapathy Sanjeev Shukla souravdatta #Breastcancer ndtv.com/education/iise…

We are glad to share our latest work on the ERK1/2-EGR1-SRSF10 axis and alternative splicing in head and neck cancer. Congratulations to Sandhya Yadav. Thank you DBT/WT India Alliance SERB DAE India IISER Bhopal.

In an exclusive #authorinterview with #biopatrika Ashok cheemala & Neha Ahuja from Sanjeev Shukla lab IISER Bhopal talks about their work on mechanism of breast cancer progression published in #Oncogenesis. Department of Biotechnology DSTIndia SERB #cancer biopatrika.com/2021/09/21/int…

Our first CSH Brain Barriers meeting was great! So much good advice. Thanks to Dritan Agalliu Rich Daneman Britta Engelhardt for helpful comments, and @SiegenthalerLab for leading an excellent meeting. And congratulations to our own Ashok cheemala on the poster prize. We’ll be back!

New preprints from our lab! biorxiv.org/cgi/content/sh… and biorxiv.org/cgi/content/sh… which show that the RNA-binding protein TDP-43 is reduced in the endothelium in neurodegenerative diseases AD and ALS/FTD, and that this reduction can cause BBB disruption.

Led by postdoc Ashok cheemala in biorxiv.org/cgi/content/sh…, we followed up on a CRISPR screen showing that the loss of TDP-43 increased TNF-mediated activation of endothelial cells, interesting b/c endothelial activation and BBB disruption is early in disease progression.

Beautiful, another key contribution to understanding TDP-43 in ECs. Please also see our preprints biorxiv.org/content/10.110… and biorxiv.org/content/10.110… showing similar BBB loss in ECs with a partial loss of nuc. TDP-43 (disease mutation), and a TDP-43 loss in ECs in human disease.

Thanks Matthew Campbell and Dionna Williams, PhD Lab for organizing a wonderful Gordon conference on barriers of the CNS, and for giving talented students Ashok cheemala and Omar a chance to present their own work. We came away with a lot of exciting new ideas!

Have you wondered if there is a role for the endothelium in regulating immune responses, beyond its function as a gatekeeper? Here, we molecularly define an immune transition of the endothelium required for chronic CD8 T cell responses in atherosclerosis biorxiv.org/content/10.110….

I'm happy to announce that our paper describing the first in human tissue application of inCITE-seq, to assess nuclear levels of RNA-binding proteins, and key regulators of the blood brain barrier (b-Catenin and NF-kB) is now available online nature.com/articles/s4159…

In parallel work (Science Advances next month and bioRxiv here : biorxiv.org/content/10.1...) from Ashok cheemala we show that targeted deletion of TDP-43 in brain ECs compromises the BBB, and leads to dysfunction of pathways disrupted in human capillaries with reduced TDP-43.

Early career excellence in neurodegenerative research | Carney Institute for Brain Science | Brown University carney.brown.edu/news/2025-02-0…

InFocus - Endothelial Dysfunction in Health & Disease members.navbo.org/calendar-of-ev…

Despite strong headwinds our work continues. Ashok cheemala shows that even a single point mutation in TDP-43 leads to large defects in cell-cell junction and barrier, and that brain endothelial deletion disrupts the BBB and leads to FTD-like behavior science.org/doi/10.1126/sc…

Congratulations to Ashok, an exceptionally talented scientist who would be a tremendous junior faculty hire. Thank you to our collaborators The Jackson Laboratory, lab members including Omar and as others not on this platform, including Riqiang Yan.

A detailed post can be found at 1patrickmurphy at bsky social, with the next questions we hope to address with input and support from NAVBO AHA Science Alzheimer's Association Alzheimer's Research UK The AFTD and NINDSfunding CSHL Meetings

New Research Reveals Blood-Brain Barrier Breakdown as a Silent Trigger of Dementia and ALS Read more: 🔗scisoup.org/article/2025/n… MurphyLab Ashok cheemala SciSoup Science Advances Ratneshwar Thakur SciCommIndia 🇮🇳

What if diseases like Alzheimer’s and ALS don’t start with damaged brain cells, but with the blood vessels that protect them? New research suggests the blood-brain barrier may break down first.