🔥Telegram İfşa

The molecular bases of kidney deficiency in cats in cat-shelters: AA amyloids #amyloidosis #cats #kidneydisease #cryoem #shelters

#cryoEM structure of ex vivo fibrils associated with extreme AA #amyloidosis prevalence in a #cat shelter, published now in Nature Communications nature.com/articles/s4146…

#Amyloid protein deposits can lead to organ failure and death. This 3.3 Å structure of AA amyloid shows unique features of deposit formation in cats and presents amyloid links between domestic #cats and #cheetahs! DOI: doi.org/10.1038/s41467… EMDB: ebi.ac.uk/emdb/EMD-14726

Newly released data (2 TB) at #EMPIAR (empiar.org/EMPIAR-11001) that led to the below #CryoEM structure of ex vivo AA #Amyloid from renal tissue of a short hair cat. Images consist of unaligned multi-frame movies & motion-corrected micrographs. #StructuralBiology #Biology

Researchers from Università di Pavia report the cryoEM structure of AA amyloid from a cat shelter with extreme disease prevalence tim.schulte, Antonio Chaves-Sanjuan, Valentina Speranzini, Stefano Ricagno, @Martinobologne2, Francesca Lavatelli go.nature.com/3Bx0ENU

I'm pleased to share with you this structure connected with a rare very debilitating human disease

Q for the cryo-EM community and Imaging_Artifact: What's the probability of two proteins with the same structure? doi.org/10.1038/srep24… and doi.org/10.1016/j.str.… or doi.org/10.1016/j.jsb.…

Happy to see our work featured in the cover of Molecular Therapy cell.com/molecular-ther…

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share our recent work on CryoEM structure of amyloid fibril extracted from kidney of an AL amyloidosis patient doi.org/10.1016/j.jmb.…. This is the first report showing identical amyloid fibril structures in different organs of same patient ! tim.schulte Stefano Ricagno

📡Un equipo CSIC patenta un aerosol q permite a las plantas retener el agua y garantizar su supervivencia, incluso si no reciben una gota de riego en 20 días 🍅Biotecnología: cómo hacer que el tomate sobreviva casi sin agua elpais.com/masterdeperiod… EL PAÍS

Hey #CryoEM community! Have you observed such features in images during data collection? What could be the reasons?

Happy to share our work on the CryoEM structure of renal fibril extracted from kidney of an AL amyloidosis patient has been selected as a cover page of Journal of Molecular Biology December issue 😊

pubmed.ncbi.nlm.nih.gov/37516426/

I'm to happy share our last preprint (10.21203/rs.3.rs-3625869/v1): we show that ex-vivo cardiac amyloids form stable and extended interactions with collagen VI, #amyloidosis, #collagen, #cryoem #heartdisease #structuralbiology

Stefano Ricagno Excited to share this serendipitous discovery. Together with Antonio Chaves-Sanjuan Valentina Speranzini Stefano Ricagno et al! researchsquare.com/article/rs-362…

Structural determinants of ivabradine block of the open pore of HCN4 | PNAS pnas.org/doi/10.1073/pn…

Happy to share our work on UvrA and UvrB DNA lesion detection finally published: Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair pubmed.ncbi.nlm.nih.gov/40210888/ #cryoEM