Long-awaited resource! A global atlas of substrate specificities for the human serine/threonine kinome biorxiv.org/content/10.110…

Excited to announce preprint from Alessi & Knapp labs describing new kinase activated by PKC isoforms through an unexpected mechanism: biorxiv.org/content/10.110… ​#LRRK2 #LRRK1 #PKC Aligning Science Across Parkinson’s LRRK2 Central

Inspiring fireside chat about the future of #LRRK2 research at the Biennial International LRRK2 Meeting #BiochemEvent

Check out the Review "#Roc, the G-domain of the Parkinson’s disease-associated protein #LRRK2" by Quyen Hoang and colleagues IU School of Medicine. #GTPase #kinase #allostery #conformationalchange #model #therapeutics bit.ly/3O5KEpL

Solving the LRRK jigsaw piece by piece: Protein kinase C switches on the LRRK1 kinase - simply by phosphorylation. portlandpress.com/biochemj/artic… @biochem_journal Asad Malik Deep Chatterjee

My visa application is stuck with UK immigration for 55 days.Paid email (£2.74/email) queries result in generic responses,paid phone calls get disconnected abruptly without giving a solution.Need to travel to Cavtat next week and need my passport! Nightmare!!!#UKVISADELAY #UKVisa

In collaboration with the Verba lab and Krogan Lab, we present the first structure of a fascinating PEAK3 pseudokinase, captured in complex with 14-3-3, and propose a mechanism by which 14-3-3 regulates PEAK3 signaling. biorxiv.org/content/10.110…

One year ago we received the funding approval for our ProxiDrugs consortium. Academic and industrial partners from the Rhein-Main-Necker region are now studying various innovative ideas in the field of proximity-inducing drugs. We are now looking for a scientific project manager.

Join UC San Diego professor Andres Leschziner for this month's LRRK2 Central seminar. 🖋️Register today: lrrk2.bio/events/coming-…

Two drugs are better than one—blocking drug action in the periphery while maintaining CNS pharmacology (mTOR, Lrrk2 and Her2). #Glioblastoma Ziyang Zhang and Waweisslab.UCSF.edu UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI College of Chemistry michaeljfox.org nature.com/articles/s4158…

📢 New research study from Professor Dario R Alessi and colleagues MRC PPU: Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding. #OpenAccess doi.org/10.1042/BCJ202…

Amazing progress presented at the #PROXIDRUGS annual meeting. Fantstastic to see our #Cluster4Future being so productive within its first year!🥳 @BMBF_Bund #Clusters4Future #Zukunftscluster

Andres Leschziner bioRxiv Structure of LRRK1 and mechanisms of autoinhibition and activation biorxiv.org/content/10.110…

many thx to Hückmann-Foundation for the support of Visiting Professorships scheme and strengthening research areas of Goethe-Universität IBC2 Max Planck Institute of Biophysics EMTHERA #ResearchClusterSCALE

The LRRK2 kinase is a major drug target for Parkinson’s Disease (PD). These structures visualize different types of kinase inhibitors binding to wildtype and PD mutant versions of LRRK2. Important advance for PD research by our @ASAP_research team.

Wow - beautiful summary movie - thank you - always a pleasure working with you! Goethe-Universität Structural Genomics Consortium (SGC) Deep Chatterjee

The more European part of our ASAP Team! Thank you Aligning Science Across Parkinson’s #CRNLondon2023 Andres Leschziner __as_n_ Kinas_s

Another collaborative effort comes together! The Knapp lab creates DARPins targeting LRRK2-one of them is not only a great tool for cryoEM (go Andres Leschziner lab!), but also disrupts LRRK2 filament formation on microtubules and acts as an allosteric LRRK2 kinase inhibitor in cells

Out Now! Our new preprint of mechanism of #PINK1 activation at TOM complex. Led by Wale OLAWALE RAIMI & Hina MRC PPU Fantastic collaboration with Ruben Fernandez Sebastian Mathea Aligning Science Across Parkinson’s Karim Labib Neil Ranson Tom Deegan. #OpenScience click here surl.li/oqvpt

Delighted to share our new study on the mechanism of #PINK1 activation at the #TOM complex. Led by Wale OLAWALE RAIMI & Hina MRC PPU UoD Life Sciences in collaboration with Ruben Fernandez & Sebastian Mathea Aligning Science Across Parkinson’s Karim Labib Neil Ranson Tom Deegan science.org/doi/10.1126/sc…