Congrats!

Nice paper by my rotation mentor Allie Greaney in which she maps SARS-CoV-2 spike receptor binding domain variants capable of escaping various human antibodies. Very cool!!!

Our paper has been published! Direct induction of oocytes from ESC/iPSCs with 4 transcription factors. "Reconstitution of the oocyte transcriptional network with transcription factors" disq.us/t/3tkhoag

Congratulations to Sam Regalado on being awarded an NRSA fellowship!

Excited to share a preprint about our project in which we aim to computationally reconstruct the cellular trajectories of mammalian embryogenesis, which started in my lab rotation at the beginning of my PhD. Many thanks to Jay Shendure and my rotation mentor Junyue !!

Excited to share this preprint biorxiv.org/content/10.110… in collaboration with Alex Sigal @khadijakhan24 at Africa Health Research Institute and Tyler Starr Rachel Eguia (and many others). Bloom Lab says it best; see 🧵👇. To add... (1/10)

Congratulations to Choi and Will! Amazing to see how fast this went from idea to reality.

It’s finally here! We built an artificial DNA-based recording system named DNA Ticker Tape – we can record the order of biological events in the genome, including those of the human cells! (1/12) biorxiv.org/content/10.110…

My interests in history makes me want to RECORD and WRITE cellular history too. How can we learn the past of a cell and understand why it is what it is right now? Can we record histories into genomes? Check out our latest preprint about ENGRAM biorxiv.org/content/10.110…

Congratulations to Hanna Liao on being awarded an NSF fellowship, and to Lincoln Harris and Chris Hsu for receiving honorable mention.

I am delighted to share THE LORAX, a method which combines cell lineage trees (get it? 😉), scRNA-seq, & scATAC-seq to explore the underpinnings of clonal cell heterogeneity! (1/12) biorxiv.org/content/10.110…

Congratulations to my wife on finishing her first year of medical school! Amazing how much she has grown as a physician in a short amount of time. Now on to a summer of research as an Alex's Lemonade News POST scholar at Seattle Children's.

Absolutely thrilled to share mine and Troy McDiarmid’s work describing the development of a multiplexed, scalable CRISPRa cell type-specific screening framework that is able to identify…(1/n) biorxiv.org/content/10.110…

Exceptionally stoked to share our new work entitled “Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements” ! biorxiv.org/content/10.110…

Thrilled to share my work describing chromatin-context dependent regulation of prime editing and our effort in leveraging this knowledge to modulate prime editing outcomes. biorxiv.org/content/10.110… 1/21

🎉Exciting news! Starting this summer, we're launching a groundbreaking lab at University of Washington! Unraveling & reconstructing mammalian germ cell & embryonic development using pluripotent stem cells, bolstered by the power of high-throughput genomics. Join us on this thrilling journey.

I spent my PhD developing novel genomic technologies, and today I am extra excited to share the last bit of this work, which is a multiplex prime editing (PE) screening framework! (1/n) biorxiv.org/content/10.110…

Our new paper “A molecular proximity sensor based on an engineered, dual-component guide RNA” is out! We describe a strategy named “P3 editing” for controlling genome editing with Protein-Protein Proximity in human cells. Thread: (1/9) biorxiv.org/content/10.110…

Thrilled to announce the opening of the Srivatsan Lab (srivatsan-lab.com) at the Fred Hutch Cancer Center. The lab will be building new sequencing technologies to understand how our cells and bodies form over the course of development.

Our work on studying chromatin context-dependent regulation of prime editing is officially out on @Cell. cell.com/cell/fulltext/…